Revisit to the Reaction ofO-Phenylene Diamine with Thiosemicarbazide to Give Benzimidazole-2-Thione Rather than Benzotriazine-2-Thione and its Glycosylation
Autor: | Mohammed R. Amer, Aly A. Aly, El Sayed H. El Ashry, Mohamed Reda Aouad |
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Rok vydání: | 2010 |
Předmět: |
Benzimidazole
Glycosylation Magnetic Resonance Spectroscopy Triazines Thiones Benzotriazine-2-thione Regioselectivity General Medicine Phenylenediamines Biochemistry Semicarbazides chemistry.chemical_compound chemistry Phenylene Diamine Genetics Molecular Medicine Organic chemistry Benzimidazoles Glycosides |
Zdroj: | Nucleosides, Nucleotides and Nucleic Acids. 29:698-706 |
ISSN: | 1532-2335 1525-7770 |
Popis: | Reaction of o-phenylene diamine with thiosemicarbazide did not give benzotriazine-2-thione 2 as reported, although the product was found to be benzimidazole-2-thione 3. Glycosylation of 3 with acetobromo sugars 4a-4b gave the respective thioglycosides 7a-7d in addition to minor products of the nucleosides 8a and 8b, in the case of the gluco- and galacto-analogs, respectively. The regioselectivity of glycosylation reaction has been investigated. |
Databáze: | OpenAIRE |
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