Revisit to the Reaction ofO-Phenylene Diamine with Thiosemicarbazide to Give Benzimidazole-2-Thione Rather than Benzotriazine-2-Thione and its Glycosylation

Autor:	Mohammed R. Amer, Aly A. Aly, El Sayed H. El Ashry, Mohamed Reda Aouad
Rok vydání:	2010
Předmět:	Benzimidazole Glycosylation Magnetic Resonance Spectroscopy Triazines Thiones Benzotriazine-2-thione Regioselectivity General Medicine Phenylenediamines Biochemistry Semicarbazides chemistry.chemical_compound chemistry Phenylene Diamine Genetics Molecular Medicine Organic chemistry Benzimidazoles Glycosides
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 29:698-706
ISSN:	1532-2335 1525-7770
Popis:	Reaction of o-phenylene diamine with thiosemicarbazide did not give benzotriazine-2-thione 2 as reported, although the product was found to be benzimidazole-2-thione 3. Glycosylation of 3 with acetobromo sugars 4a-4b gave the respective thioglycosides 7a-7d in addition to minor products of the nucleosides 8a and 8b, in the case of the gluco- and galacto-analogs, respectively. The regioselectivity of glycosylation reaction has been investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c76595393602f79e42efa79a54fc115 https://doi.org/10.1080/15257770.2010.501777 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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