Effects of chronic hypoxia on the secretory responses of rat salivary glands
| Autor: | Juan C. Elverdin, A.B. Frid, Ana P. Chiarenza, M.J. Giglio |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Submandibular Gland Femoral vein Biology Substance P Xerostomia Methoxamine Salivary Glands Internal medicine Isoprenaline medicine Animals Parotid Gland Rats Wistar Hypoxia Saliva General Dentistry Methacholine Chloride Isoproterenol Cell Biology General Medicine Hypoxia (medical) Stimulation Chemical Parotid gland Rats Dose–response relationship medicine.anatomical_structure Endocrinology Otorhinolaryngology Barotrauma Chronic Disease Methacholine Female medicine.symptom Secretory Rate Intracellular medicine.drug |
| Zdroj: | Archives of oral biology. 40(5) |
| ISSN: | 0003-9969 |
| Popis: | Female Wistar rats were placed for 3 weeks in a simulated chamber evacuated by a vacuum pump and maintained at 40.5 kPa (7100 m). Dose response curves were obtained through the sequential injection, via the femoral vein, of increasing doses of methacholine, methoxamine, isoprenaline and substance P. The secretory activity in the parotid gland after exposure to chronic hypoxia was significantly decreased for all agonists studied, and the submaxillary gland showed the same behaviour except in relation to isoprenaline, which did not show a significant difference compared to controls. These data suggest that changes in the number or sensitivity of autonomic receptors and/or alterations in the intracellular signals caused by hypoxia may be involved in the reduction in salivary secretory responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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