T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017
| Autor: | Akira Wakatsuki, Hitoshi Otsuka, Midori Kimura, Yuki Kimura, Kentaro Tomari, Haruo Watanabe, Yusuke Sato, Fumiko Saka, Noriko Nakanishi, Miyuki Suzuki, Yuko Matsumoto, Yumi Uchitani, Kaoru Uchida, Tadayoshi Ikebe, Kazuki Chiba, Hirotoshi Iwasawa, Aya Shinohara, Toshinobu Hoshi, Ryouko Kikuchi, Go Sato, Mari Sasaki, Hajime kurosawa, Rumi Okuno, Keiko Ogawa, Chikara Nakagawa, Yuko Kiguchi, Ryutaro Murayama, Megumi Okada, Yuki Abe, Junji Seto, Jun Kawase, Keiji Funatogawa, Takahiro Yamaguchi, Kaori Iwabuchi, Yoshiko Kanda, Hideaki kariya, Masaki Hiragakiuchi, Tae Taniwaki, Takahiro Hiratsuka, Takako Yoshida, Youko Iwashita, Miki Nagata, Kaori Sato, Makoto Ohnishi, Sakura Iwashita, Takayuki Konno, Makiko Noda, Yukiko Kadokura, Shuntaro Umeda, Kayoko Nakaoka, Kazunori Kishida, Takaya Yamagami, Kouji Takeuchi, Tomoe Sao, Tetsuya Kakita, Yo Morimoto, Yumi Akiyama, Eiko Yuzawa, Yukiko Igawa, Kazunari Yamamoto, Hiroko Akita, Masato Miyahira, Shinichiro Shibata, Takayuki Shiomoto, Hitomi Ohya |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Serotype Streptococcus pyogenes 030106 microbiology Human pathogen medicine.disease_cause Group A Microbiology 03 medical and health sciences 0302 clinical medicine Japan Streptococcal Infections medicine Humans Pharmacology (medical) 030212 general & internal medicine Serotyping Streptococcus business.industry Pharyngitis Effective management Shock Septic Infectious Diseases Streptococcal toxic shock syndrome medicine.symptom business |
| Zdroj: | Journal of Infection and Chemotherapy. 26:157-161 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2019.10.010 |
| Popis: | Streptococcus pyogenes (group A streptococcus; GAS) is an important gram-positive human pathogen capable of causing diseases ranging from mild superficial skin and pharyngeal infections to more severe invasive diseases, including streptococcal toxic shock syndrome (STSS). GAS produces a T protein, and T serotyping has considerable discriminatory power for epidemiological characterization of GAS. To clarify the relationship between STSS and pharyngitis in Japan, we examined the T serotypes of GAS strains isolated from clinical specimens of streptococcal infections (STSS, 951 isolates; pharyngitis, 16268 isolates) from 2005 to 2017. The most prevalent T serotype from pharyngitis isolates was T12, followed by T1, T4, and TB3264. The most prevalent T serotype from STSS isolates was T1, followed by TB3264. Trend of increase and decrease in the frequency of T1 or TB3264 isolation from pharyngitis was correlated with that of STSS patients. The increase of T1 or TB3264 strain-infection in pharyngitis patients may increase the probability of causing STSS, indicating that careful monitoring of GAS serotypes is essential for the prediction of rapid increase of STSS in time to develop effective management strategies. |
| Databáze: | OpenAIRE |
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