Evaluation of renal function with delayed CT after injection of nonionic monomeric and dimeric contrast media in healthy volunteers
| Autor: | D T Kristoffersen, Jarl Å. Jakobsen, K. J. Berg, K. W. Borch, J K Hald, B. Lundby |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Renal function Diuresis Contrast Media Kidney Kidney Function Tests Iopamidol Excretion chemistry.chemical_compound Reference Values Internal medicine Triiodobenzoic Acids Acetylglucosaminidase medicine Humans Radiology Nuclear Medicine and imaging Creatinine business.industry Osmolar Concentration Alkaline Phosphatase Iodixanol medicine.anatomical_structure Endocrinology chemistry Alkaline phosphatase business Tomography X-Ray Computed beta 2-Microglobulin medicine.drug |
| Zdroj: | Radiology. 182(2) |
| ISSN: | 0033-8419 |
| Popis: | A new nonionic dimeric contrast medium (CM), iodixanol, was intravenously administered to 40 healthy male volunteers in doses of 0.3-1.2 g of iodine per kilogram of body weight, nonionic monomeric iopamidol and iopentol were administered to 20 others, and the renal effects were studied up to 120 hours after administration. Computed tomography of the kidneys was performed up to 80 hours after injection. Creatinine clearance as an index of the glomerular filtration rate was unchanged with all CM. Urine volume and osmolar clearance increased most with the monomeric CM. The proximal tubular brush border enzyme alkaline phosphatase increased with all CM. The lysosomal enzyme N-acetyl-beta-glucosaminidase increased more with the monomeric CM than with iodixanol. A persistent increased attenuation in the region of the cortex was observed with all CM. Attenuation returned to baseline within 80 hours, with the slowest decline with iodixanol. This delayed cortical enhancement did not correlate with the effects of the CM on the tubular enzyme excretion. |
| Databáze: | OpenAIRE |
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