A Case of Small Polypoid Esophageal Carcinoma With Multidirectional Differentiation, Including Neuroendocrine, Squamous, Ciliated Glandular, and Sarcomatous Components

Autor:	A, Kanamoto, Y, Nakanishi, A, Ochiai, T, Shimoda, H, Yamaguchi, Y, Tachimori, H, Kato, H, Watanabe
Rok vydání:	2000
Předmět:	Male Esophageal Neoplasms Cell Differentiation Muscle Smooth General Medicine Adenocarcinoma Middle Aged Immunohistochemistry Actins Carcinoma Neuroendocrine Pathology and Forensic Medicine Medical Laboratory Technology Carcinosarcoma Carcinoma Squamous Cell Chromogranins Humans Keratins
Zdroj:	Archives of Pathology & Laboratory Medicine. 124:1685-1687
ISSN:	1543-2165 0003-9985
DOI:	10.5858/2000-124-1685-acospe
Popis:	A small composite esophageal carcinoma measuring 1.5 × 1.4 × 1.0 cm is described. The tumor had a polypoid elevation with a superficial extension. Histologic examination revealed invasion of the submucosal layer and multidirectional differentiation, including neuroendocrine, squamous, ciliated glandular, and sarcomatous components. The neuroendocrine component was strongly positive for chromogranin and formed the bulk of the polypoid tumor. The squamous cell carcinoma exhibited a superficial extension. The adenocarcinoma was located in a small region of the tumor and contained ciliated glandular cells. The spindle cell sarcomatous component, which was positive for α-smooth muscle actin and negative for cytokeratin, exhibited no specific mesenchymal differentiation. Each component was found in 60%, 10%, 5%, and 25% of the tumor, respectively. Cases of small composite esophageal carcinoma containing various carcinomatous and sarcomatous components are extremely rare.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c719acbd57a8dbfe373e05822550d33 https://doi.org/10.5858/2000-124-1685-acospe Zobrazit plný text záznamu