Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans
| Autor: | Anna Evangelista, Angelo Pirisi, Speranza Rubattu, David Tarasi, Bruna Gigante, Massimo Volpe, Rosita Stanzione, Emanuele Di Angelantonio, Bastianina Zanda, Ercole Brunetti |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Genotype medicine.drug_class Gene mutation Brain Ischemia Atrial natriuretic peptide Gene Frequency Recurrence Internal medicine Natriuretic peptide Medicine Humans Genetic Predisposition to Disease Allele Risk factor Stroke Aged Advanced and Specialized Nursing Polymorphism Genetic cerebrovascular disorders gene mutation genetics natriuretic peptides atrial receptors atrial natriuretic factor business.industry Middle Aged medicine.disease Genotype frequency Endocrinology Guanylate Cyclase Case-Control Studies Mutation Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Receptors Atrial Natriuretic Factor Atrial Natriuretic Factor |
| Zdroj: | Stroke 4 (2004): 814–818. info:cnr-pdr/source/autori:Rubattu S, Stanzione R, Di Angelantonio E, Zanda B, Evangelista A, Tarasi D, Gigante B, Pirisi A, Brunetti E, Volpe M/titolo:Atrial natriuretic peptide gene Polymorphisms and risk of ischemic stroke in humans/doi:/rivista:Stroke/anno:2004/pagina_da:814/pagina_a:818/intervallo_pagine:814–818/volume:4 |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose— A precise definition of genetic factors responsible for common forms of stroke is still lacking. The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide ( ANP ) and type A natriuretic peptide receptor ( NPRA ) in humans’ susceptibility to develop ischemic stroke. Methods— Allele and genotype frequencies of ANP and NPRA were characterized in an Italian case-control study with patients affected by vascular disease or risk factors. Subjects were recruited from the island of Sardinia (206 cases, 236 controls). Results— A significant association between the ANP /TC2238 polymorphic site and stroke occurrence was found when a recessive model of inheritance was assumed. The risk conferred by this mutant genotype, when estimated by multivariate logistic regression analysis, was 3.8 (95% confidence interval, 1.4 to 10.9). A significantly increased risk of stroke recurrence was observed among cases carrying the ANP /CC2238 genotype compared with cases carrying the ANP /TT2238 genotype ( P =0.04). No direct association of NPRA with stroke occurrence was detected. However, a significant epistatic interaction between the ANP /CC2238 genotype and an allelic variant of NPRA led to a 5.5-fold increased risk of stroke (95% confidence interval, 1.5 to 19.4). Conclusions— Our findings support a direct contributory role of ANP to stroke in humans. A significant interaction between ANP and NPRA on stroke occurrence was found. |
| Databáze: | OpenAIRE |
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