Metabolic and Genetic Risk Factors for Migraine in Children
| Autor: | Maria Grazia Calevo, L Montaldi, Angelo Claudio Molinari, ME Celle, Edvige Veneselli, F Bottini, Giuseppe Minniti, Stefano Amato, D Di Pasquale, R Cerone |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Homocysteine Migraine Disorders Comorbidity 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences chemistry.chemical_compound Folic Acid 0302 clinical medicine Metabolic Diseases Risk Factors Internal medicine Prevalence medicine Factor V Leiden Humans Genetic Predisposition to Disease Vitamin B12 Risk factor Child Stroke Methylenetetrahydrofolate Reductase (NADPH2) Methionine biology business.industry Thrombosis General Medicine medicine.disease Endocrinology Italy Migraine chemistry Child Preschool Methylenetetrahydrofolate reductase Mutation biology.protein Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Cephalalgia. 26:731-737 |
| ISSN: | 1468-2982 0333-1024 |
| Popis: | Migraine can induce ischaemic stroke, and is considered an independent risk factor for stroke in the young. To date, the nature of the link between migraine and stroke is essentially unknown. Forty-five children were studied. Homocysteine levels (fasting and post methionine load), vitamin B12 and plasma folate levels, factor V Leiden, factor II G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations were examined. Compared with controls, patients with migraine had higher levels of post-methionine load homocysteine values (19.5 ± 4.9 vs. 16.9 ± 1.9; P = 0.025) and significantly lower folate levels (5.8 ± 2.6 vs. 7.5 ± 2.1; P = 0.002). We found a trend toward an increased risk of migraine in subjects carrying a homozygous mutant genotype for MTHFR C677T and MTHFR A1298C polymorphisms. Genetic prothrombotic conditions do not seem to be related to migraine in the young, whereas the biochemical differences between migrainous patients and controls are an appealing topic for further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|