Ceftriaxone-Resistant Nontyphoidal Salmonella from Humans, Retail Meats, and Food Animals in the United States, 1996-2013
Autor: | Martha Iwamoto, Jean M. Whichard, Jared Reynolds, Barbara E. Mahon, Robert M. Hoekstra, Jodie R. Plumblee, Heather Tate, Beth E. Karp, Paula J. Fedorka-Cray |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Salmonella Adolescent 030106 microbiology Enteric bacteria Food Contamination Microbial Sensitivity Tests Biology medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Poultry 03 medical and health sciences Young Adult Antibiotic resistance Drug Resistance Multiple Bacterial medicine Animals Humans Child Aged Public health Ceftriaxone Infant Monitoring system Middle Aged United States Anti-Bacterial Agents Red Meat 030104 developmental biology Child Preschool Food Microbiology Animal Science and Zoology Female Salmonella Food Poisoning Food Science medicine.drug |
Zdroj: | Foodborne pathogens and disease. 14(2) |
ISSN: | 1556-7125 |
Popis: | Ceftriaxone resistance in Salmonella is a serious public health threat. Ceftriaxone is commonly used to treat severe Salmonella infections, especially in children. Identifying the sources and drivers of ceftriaxone resistance among nontyphoidal Salmonella is crucial.The National Antimicrobial Resistance Monitoring System (NARMS) tracks antimicrobial resistance in foodborne and other enteric bacteria from humans, retail meats, and food animals. We examined NARMS data reported during 1996-2013 to characterize ceftriaxone-resistant Salmonella infections in humans. We used Spearman rank correlation to examine the relationships between the annual percentage of ceftriaxone resistance among Salmonella isolates from humans with isolates from retail meats and food animals.A total of 978 (2.9%) of 34,100 nontyphoidal Salmonella isolates from humans were resistant to ceftriaxone. Many (40%) ceftriaxone-resistant isolates were from children younger than 18 years. Most ceftriaxone-resistant isolates were one of three serotypes: Newport (40%), Typhimurium (26%), or Heidelberg (12%). All were resistant to other antimicrobials, and resistance varied by serotype. We found statistically significant correlations in ceftriaxone resistance between human and ground beef Newport isolates (r = 0.83), between human and cattle Typhimurium isolates (r = 0.57), between human and chicken Heidelberg isolates (r = 0.65), and between human and turkey Heidelberg isolates (r = 0.67).Ceftriaxone resistance among Salmonella Newport, Typhimurium, and Heidelberg isolates from humans strongly correlates with ceftriaxone resistance in isolates from ground beef, cattle, and poultry, respectively. These findings support other lines of evidence that food animals are important reservoirs of ceftriaxone-resistant Salmonella that cause human illness in the United States. |
Databáze: | OpenAIRE |
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