MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors
| Autor: | Anna Rubartelli, Maria Elisabetta Cosulich, Maria Rosaria Mazza, Angela Risso, Antonio Bargellesi |
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| Rok vydání: | 1989 |
| Předmět: |
T-Lymphocytes
Palatine Tonsil Immunology Naive B cell B-cell receptor Receptors Antigen T-Cell Thymus Gland Biology Lymphocyte Activation Mice Animals Humans Immunology and Allergy Cytotoxic T cell Phosphorylation Antigen-presenting cell B-Lymphocytes Membrane Glycoproteins Stem Cells T-cell receptor CD28 T lymphocyte Molecular biology Thymocyte Antigens Surface Signal Transduction |
| Zdroj: | European Journal of Immunology. 19:323-328 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830190216 |
| Popis: | MLR3 molecule is a membrane glycoprotein (mol. mass range 28-34 kDa) present on activated, but not resting human peripheral T cells, B cells and thymocytes. Its kinetics of appearance on the cell surface (3 h after the addition of the inductive signal to the cells) suggests that it is an early activation antigen. The proliferative response of cultured T and B lymphocytes and thymocytes to different activation signals is inhibited by the addition of MLR3 monoclonal antibody. Moreover the antibody in combination with non-mitogenic doses of phorbol myristate acetate leads to proliferation of thymocytes and resting B and T lymphocytes. In the latter, synthesis of interleukin 2 is also induced. Biochemical analysis of MLR3 antigen indicates that it is a phosphorylated protein with N-linked sugar moieties. Together these data suggest a role for MLR3 antigen in the signal transduction process during activation, both for mature lymphocytes and for T cell precursors. |
| Databáze: | OpenAIRE |
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