Penetration of synthetic corticosteroids into human aqueous humour
| Autor: | A I Fern, Charles N J McGhee, David G. Watson, Gordon N. Dutton, M J Noble, John M. Midgley |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Prednisolone Alcohol Gas Chromatography-Mass Spectrometry Aqueous Humor chemistry.chemical_compound Betamethasone Sodium Phosphate Pharmacokinetics Internal medicine medicine Humans Fluorometholone Aged Aged 80 and over Chromatography Aqueous humour Middle Aged Ophthalmology Prednisolone Sodium Phosphate Endocrinology chemistry Corticosteroid Ophthalmic Solutions medicine.drug |
| Zdroj: | Eye (London, England). 4 |
| ISSN: | 0950-222X |
| Popis: | The penetration of prednisolone acetate (1%) and fluorometholone alcohol (0.1%) into human aqueous humour following topical application was determined using the very sensitive and specific technique of Gas Chromatography with Mass Spectrometry (GCMS). Prednisolone acetate afforded peak mean concentrations of 669.9 ng/ml within two hours and levels of 28.6 ng/ml in aqueous humour were detected almost 24 hours post application. The peak aqueous humour level of fluorometholone was 5.1 ng/ml. The results are compared and contrasted with the absorption of dexamethasone alcohol (0.1%), betamethasone sodium phosphate (0.1%) and prednisolone sodium phosphate (0.5%) into human aqueous humour. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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