Comparison of ipsilateral breast tumor recurrence after breast-conserving surgery between ductal carcinoma in situ and invasive breast cancer

Autor: Young Duck Shin, Young Jin Song, Young Jin Choi
Jazyk: angličtina
Předmět:
0301 basic medicine
Oncology
Survival
medicine.medical_treatment
Mastectomy
Segmental
0302 clinical medicine
Ductal carcinoma in situ (DCIS)
Breast-conserving surgery
skin and connective tissue diseases
Margin
Carcinoma
Ductal
Breast
Middle Aged
Prognosis
Survival Rate
030220 oncology & carcinogenesis
Resection margin
Female
Breast carcinoma
Ipsilateral breast tumor recurrence (IBTR)
Adult
medicine.medical_specialty
Breast Neoplasms
Breast-conserving surgery (BCS)
Young Adult
03 medical and health sciences
Breast cancer
Internal medicine
medicine
Adjuvant therapy
Humans
Neoplasm Invasiveness
Survival rate
Aged
Neoplasm Staging
Retrospective Studies
Radiotherapy
business.industry
Research
medicine.disease
Radiation therapy
Carcinoma
Lobular
Carcinoma
Intraductal
Noninfiltrating
030104 developmental biology
Surgery
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: World Journal of Surgical Oncology
ISSN: 1477-7819
DOI: 10.1186/s12957-016-0885-6
Popis: Background We aimed to evaluate the differences in the rates and predictive factors for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) between ductal carcinoma in situ (DCIS) and invasive breast cancer. And, we evaluated the impact of IBTR on overall survival and distant metastasis. Methods We retrospectively reviewed 322 consecutive patients with DCIS or invasive breast cancer who underwent BCS between 2004 and 2010. We evaluated the rates of IBTR of DCIS and invasive breast cancer. Univariate and multivariate analyses were performed to determine the predictive factors for IBTR, and survival rates were analyzed with Kaplan-Meier estimates. Results With a median follow-up period of 57 months, 5 (10 %) out of 50 DCIS patients and 14 (5.1 %) out of 272 invasive cancer patients had developed IBTR. Factors associated with IBTR on univariate and multivariate analyses were positive resection margin status in DCIS and omission of radiotherapy in invasive cancer, respectively. The hormone receptor negativity was strong independent predictive factors for IBTR in both DCIS and invasive breast cancer. Although the differences of survival curve did not reach statistical significance, the 5-year overall survival and distant metastasis-free survival of invasive cancer patients who suffered IBTR were inferior to those without (84 vs. 98 % and 63.3 vs. 96.5 %, respectively). Advanced initial stage, lymph node metastasis and experience of IBTR were associated with poor overall survival and distant metastasis on univariate and multivariate analyses. Conclusions The hormone receptor negativity was revealed as independent predictive factor for IBTR after BCS in both DCIS and invasive cancer. Experience of IBTR was independent prognostic factor for poor overall outcome in patients with invasive breast cancer. Aggressive local control and adjuvant therapy should be made in hormone receptor-negative patients who receive treatment with BCS.
Databáze: OpenAIRE
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