Acute effect of glycerol on net cerebrospinal fluid production in dogs
| Autor: | Sada Okumura, Marvin A. Fishman, Huda Y. Zoghbi, John P. Laurent |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Osmole
Glycerol medicine.medical_specialty business.industry Osmolar Concentration Acute effect Baseline level Blood Physiological Phenomena chemistry.chemical_compound Endocrinology Cerebrospinal fluid Dogs chemistry Oral administration Internal medicine medicine Serum osmolality Animals business Production rate Cerebrospinal Fluid |
| Zdroj: | Journal of neurosurgery. 63(5) |
| ISSN: | 0022-3085 |
| Popis: | ✓ The effect of glycerol administration on cerebrospinal fluid (CSF) formation in dogs was studied by means of a ventriculocisternal perfusion technique. Net CSF production rate decreased after oral administration of glycerol (3 gm/kg) from a baseline level of 42.33 ± 6.68 µl/min (mean ± standard error) to a trough of 10.33 ± 4.88 µl/min at 90 minutes after administration (p < 0.025). Serum osmolality concomitantly increased from a baseline value of 296 ± 2.83 to 309 ± 4.7 mOsm/kg H2O at 90 minutes. The mean percentage change in CSF production inversely correlated to the mean percentage change in serum osmolality, r = −0.85. Thus, glycerol administration decreases net CSF formation, and this effect may be related in part to the rise in serum osmolality. |
| Databáze: | OpenAIRE |
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