Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

Autor: Shukri F. Mohamed, Issa Guiraud, Nigel J. Crowther, Tilahun Nigatu Haregu, Francesc Xavier Gómez-Olivé, Osman Sankoh, Hamtandi Magloire Natama, H. Sorgho, Seydou Nakanabo-Diallo, Lucas Amenga-Etego, Lisa K. Micklesfield, Christopher Khayeka-Wandabwa, Romuald P. Boua, Depuur C, Shane A. Norris, Stephen Tollman, Engelbert A. Nonterah, Godfred Agongo, Alisha N. Wade, Athanase M Some, Catherine Kyobutungi, Marianne Alberts, Cassandra Soo, Nicholas Ngomi, Stuart A. Ali, Rhian Twine, Scott Hazelhurst, Zané Lombard, Kathleen Kahn, Ananyo Choudhury, Abraham Oduro, Freedom Mukomana, Felistas Mashinya, Paulina Tindana, Michèle Ramsay, Halidou Tinto
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Burden of disease
Adult
Male
Cross-sectional study
Population
burden of disease
African populations
03 medical and health sciences
South Africa
0302 clinical medicine
Environmental risk
Metabolic Diseases
Risk Factors
Environmental health
parasitic diseases
Medicine
Humans
030212 general & internal medicine
AWI-Gen
Metabolic disease
education
Aged
Aged
80 and over
education.field_of_study
Geography
business.industry
Study Design Article
Health Policy
lcsh:Public aspects of medicine
1. No poverty
Public Health
Environmental and Occupational Health
Age Factors
lcsh:RA1-1270
Genomics
Middle Aged
Cardiometabolic disease
3. Good health
H3Africa
030104 developmental biology
Cross-Sectional Studies
Cardiovascular Diseases
Population Surveillance
Female
Gene-Environment Interaction
sense organs
business
Genome-Wide Association Study
Zdroj: Global Health Action, Vol 11, Iss 0 (2018)
Global Health Action
ISSN: 1654-9880
1654-9716
Popis: There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent.
Databáze: OpenAIRE
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