Prevalence of oropharyngeal dysphagia in hereditary spastic paraplegias
| Autor: | Daniela Burguêz, Carelis González-Salazar, Annelise Ayres, Jonas Alex Morales Saute, Márcia Polese-Bonatto, Marcondes Cavalcante França Junior, Gustavo Dariva Machado, Marina Siebert, Laís Alves Jacinto-Scudeiro, Maira Rozenfeld Olchik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Spastic paraplegia hereditary Cross-sectional study Deglutição Gastroenterology Severity of Illness Index 0302 clinical medicine Risk Factors Surveys and Questionnaires Spastic Prevalence Medicine deglutition deglutição xantomatose cerebrotendinosa 0303 health sciences 030305 genetics & heredity Xanthomatosis Cerebrotendinous Middle Aged Dysphagia transtornos da deglutição Neurology Female medicine.symptom Paraplegia Paraplegia espástica hereditária Brazil RC321-571 Adult medicine.medical_specialty Neurosciences. Biological psychiatry. Neuropsychiatry Cerebrotendinous Xanthomatosis 03 medical and health sciences Transtornos de deglutição Age Distribution Swallowing Internal medicine Severity of illness otorhinolaryngologic diseases Humans Sex Distribution Aged xanthomatosis cerebrotendinous business.industry deglutition disorders medicine.disease Deglutition Cross-Sectional Studies Neurology (clinical) business Deglutition Disorders 030217 neurology & neurosurgery Xantomatose cerebrotendinosa Oropharyngeal dysphagia |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 77, Iss 12, Pp 843-847 (2020) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Arquivos de Neuro-Psiquiatria, Volume: 77, Issue: 12, Pages: 843-847, Published: 10 JAN 2020 Arquivos de Neuro-Psiquiatria v.77 n.12 2019 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| ISSN: | 1678-4227 |
| Popis: | Hereditary spastic paraplegias (HSP) are a group of genetic diseases characterized by lower limb spasticity with or without additional neurological features. Swallowing dysfunction is poorly studied in HSP and its presence can lead to significant respiratory and nutritional complications. Objectives: The aim of this study was to evaluate the frequency and clinical characteristics of dysphagia in different types of HSP. Methods: A two-center cross-sectional prevalence study was performed. Genetically confirmed HSP patients were evaluated using the Northwestern Dysphagia Patient Check Sheet and the Functional Oral Intake Scale. In addition, self-perception of dysphagia was assessed by the Eat Assessment Tool-10 and the Swallowing Disturbance Questionnaire. Results: Thirty-six patients with spastic paraplegia type 4 (SPG4), five with SPG11, four with SPG5, four with cerebrotendinous xanthomatosis (CTX), three with SPG7, and two with SPG3A were evaluated. Mild to moderate oropharyngeal dysphagia was present in 3/5 (60%) of SPG11 and 2/4 (50%) of CTX patients. A single SPG4 (2%) and a single SPG7 (33%) patient had mild oropharyngeal dysphagia. All other evaluated patients presented with normal or functional swallowing. Conclusions: Clinically significant oropharyngeal dysphagia was only present in complicated forms of HSP Patients with SPG11 and CTX had the highest risks for dysphagia, suggesting that surveillance of swallowing function should be part of the management of patients with these disorders. RESUMO As paraparesias espásticas hereditárias (PEH) são um grupo de doenças genéticas caracterizado por espasticidade dos membros inferiores com ou sem características neurológicas adicionais. A disfunção da deglutição é pouco estudada nas PEH e sua presença pode levar a complicações respiratórias e nutricionais significativas. Objetivo: O objetivo deste estudo foi avaliar a frequência e a caracterização clínica da disfagia em diferentes tipos de PEH. Métodos: Foi realizado um estudo transversal em dois centros. Os pacientes com PEH confirmados geneticamente foram avaliados pelo Northwestern Dysphagia Patient Check Sheet e pela Escala Funcional de Ingestão Oral. Além disso, a autopercepção da disfagia foi avaliada pelo Eat Assessment Tool-10 e pelo Swallowing Disturbance Questionnaire. Resultados: Trinta e seis pacientes com paraplegia espástica tipo 4 (SPG4), cinco com SPG11, quatro com SPG5, quatro com xantomatose cerebrotendinosa (CTX), três com SPG7 e dois com SPG3A foram avaliados. Disfagia orofaríngea leve a moderada estava presente em 3/5 (60%) dos pacientes com SPG11 e 2/4 (50%) dos pacientes com CTX. Um único SPG4 (2%) e um único SPG7 (33%) apresentaram disfagia orofaríngea leve. Todos os outros pacientes avaliados apresentaram deglutição normal ou funcional. Conclusão: Disfagia orofaríngea clinicamente significativa estava presente apenas nas formas complicadas de PEH. A SPG11 e CTX apresentaram maiores riscos de disfagia, sugerindo que a avaliação da deglutição deve fazer parte do manejo dos pacientes com essas condições. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|