Rhesus CE expression on patient red blood cells is an independent prognostic factor for adenocarcinoma of the lung
| Autor: | Andreas Kuemmel, G. Geißler, Wolfgang E. Berdel, Arik Bernard Schulze, Michael Mohr, LH Schmidt, Dennis Görlich, Birthe Heitkötter, L Baie, Roland Buhl, Wolfgang Hartmann, R. Kelsch, Rainer Wiewrodt, H. Hillmann |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Prognostic factor Erythrocytes Lung Neoplasms Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Germany Internal medicine Biomarkers Tumor medicine Adenocarcinoma of the lung Humans Immunology and Allergy Stage (cooking) Lung cancer Genetics (clinical) Neoplasm Staging Rh-Hr Blood-Group System business.industry Incidence (epidemiology) Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Disease Progression Adenocarcinoma Female business |
| Zdroj: | The Clinical Respiratory Journal. 12:1106-1117 |
| ISSN: | 1752-6981 |
| DOI: | 10.1111/crj.12638 |
| Popis: | OBJECTIVES The influence of blood group antigens on cancerogenesis is shown for distinct tumor types, yet the impact of Rhesus blood group antigens in lung cancer is not clarified. MATERIALS AND METHODS To investigate the impact of Rhesus blood groups a non-small cell lung cancer (NSCLC) collective (n = 1047) was analyzed retrospectively. Using a second cohort of n = 340 primarily operated stage I-III NSCLC patients, we evaluated immunohistochemistry of CD47-antibody stained tissue samples in correlation to histopathologic subtype and Rhesus blood group. RESULTS AND CONCLUSION In 516 of 1047 patients blood group data were available. Seven different RhCE phenotypes were grouped as "··ee," "ccE·," and "C·E·." Adenocarcinoma patients with Rh "··ee" revealed improved overall survival (29 (21.2-36.8) m; HR 1.00 [index]) compared with Rh "ccE·" (19 (1.9-36.1) m; HR 1.76 [1.15-2.70]) and Rh "C·E·" (10 (7.4-12.6) m; HR 2.65 [1.70-4.12]) univariately (P |
| Databáze: | OpenAIRE |
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