Retrospective survey to evaluate the safety and efficacy of Japanese botulinum antitoxin therapy in Japan
| Autor: | Motohide Takahashi, Masaaki Iwaki, Shunji Kozaki, Keita Mottate, Shigemi Mori, Yasushi Torii, Akihiro Ginnaga, Hiroyuki Yokote, Yoshinobu Miyatsu, Akira Horita |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Side effect 030106 microbiology Botulinum Antitoxin Toxicology Severity of Illness Index complex mixtures Young Adult 03 medical and health sciences 0302 clinical medicine Japan Retrospective survey Internal medicine Case fatality rate Severity of illness medicine Humans Botulism 030212 general & internal medicine Child Aged Retrospective Studies Public Health Informatics business.industry Retrospective cohort study Middle Aged medicine.disease Survival Analysis Surgery Health Care Surveys Female Antitoxin business |
| Zdroj: | Toxicon. 110:12-18 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2015.11.010 |
| Popis: | Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were used, and retrospectively analyzed the safety and efficacy of the therapy. A total of 134 patients administered botulinum antitoxins were identified from published reports. Two cases of side effects (1.5%) were detected after antitoxin administration, both not fatal. The fatality rate was 9.4%, and more than 70% of the patients showed improvement in their symptoms and better clinical conditions than those not treated with antitoxins. These data suggest that the therapy with Japanese antitoxins is safe and highly effective. |
| Databáze: | OpenAIRE |
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