A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones
| Autor: | Stephen R. Bolsover, Nicola A. Parkinson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Molecular Sequence Data
Biology ADCY10 Antibodies Adenylyl cyclase Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Calmodulin Ganglia Spinal medicine Cyclic AMP Animals Amino Acid Sequence Molecular Biology Cells Cultured Cell Nucleus Neurons ADCY6 ADCY5 ADCY9 ADCY3 Immunohistochemistry Sensory neuron Rats Isoenzymes medicine.anatomical_structure chemistry Biochemistry Calcium Neuron Adenylyl Cyclases |
| Zdroj: | Brain research. Molecular brain research. 91(1-2) |
| ISSN: | 0169-328X |
| Popis: | Calcium/calmodulin-sensitive adenylyl cyclases are increasingly recognised as important factors in memory formation and synaptic plasticity. We have examined the distributions of adenylyl cyclases types I, III, and VIII within rat primary sensory neurons. Immunofluorescence revealed distinct staining for adenylyl cyclases type I and III, but not adenylyl cyclase type VIII, within the cell nucleus. Western blots suggest that a processed form of adenylyl cyclase type III may be found within primary neurons and PC12 cells as a 70-kDa protein. We propose that the observed nuclear adenylyl cyclases are soluble forms of the cyclases. |
| Databáze: | OpenAIRE |
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