General anesthesia with an injectable 8% v/v sevoflurane lipid emulsion administered intravenously to dogs
| Autor: | Ruben Lundgren Cavalcanti, Alexandre da Silva Polydoro, Priscila Beatriz da Silva Serpa, Luiz C. P. Santos, Cláudio Corrêa Natalini, Joanna E. Griffith, Anthony Nicholson |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Methyl Ethers Minimum alveolar concentration Fat Emulsions Intravenous Respiratory rate 040301 veterinary sciences Anesthesia General Sevoflurane 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Dogs 030202 anesthesiology medicine Animals Blood urea nitrogen General Veterinary Dose-Response Relationship Drug business.industry 04 agricultural and veterinary sciences medicine.disease Respiratory acidosis Blood pressure Anesthesia Anesthesia Recovery Period Anesthesia Intravenous Female Propofol business medicine.drug |
| Zdroj: | Veterinary anaesthesia and analgesia. 43(3) |
| ISSN: | 1467-2995 |
| Popis: | To evaluate the potential of an intravenous (IV) sevoflurane formulation for maintenance of general anesthesia in dogs.Prospective crossover design.Six healthy, mature, mixed-breed dogs, four males and two females, weighing 11.7 ± 3.4 kg.Anesthesia was induced and maintained with propofol IV for instrumentation. Baseline measurements were recorded before administration of either sevoflurane in oxygen (Sevo-Inh) or lipid-emulsified sevoflurane 8% v/v in 30% Intralipid IV (Sevo-E), 0.5 mL kg(-1) over 5 minutes followed by an infusion at 0.1-0.3 mL kg(-1) minute(-1) . Dogs were breathing spontaneously. The 'up-and-down' technique was used to determine the minimum alveolar concentration (MAC) of sevoflurane. Over 120 minutes, a tail clamp was applied every 15 minutes and sevoflurane administration was adjusted depending on the response. End-tidal sevoflurane concentration and variables were recorded at 30, 60, 90, and 120 minutes: heart rate (HR), systemic arterial pressure (sAP), respiratory rate (fR ), end-tidal carbon dioxide tension, hemoglobin oxygen saturation (SaO2 ), arterial pH and blood gases, blood urea nitrogen, alanine aminotransferase, creatine kinase, gamma-glutamyl transferase, and aspartate aminotransferase.There were no significant differences between treatments for HR, sAP, fR , SaO2 , and biochemical variables (p 0.05). pH and HCO3-were significantly decreased, and PaCO2 increased from baseline in Sevo-E (p 0.05). MAC was significantly lower for Sevo-E than for Sevo-Inh, although the required dose of sevoflurane (g hour(-1) ) to maintain general anesthesia was not significantly different between treatments.Administration of 8% v/v sevoflurane lipid emulsion IV was effective in maintaining general anesthesia in dogs, but resulted in moderate cardiopulmonary depression, metabolic and respiratory acidosis. The amount of sevoflurane (g hour(-1) ) required to maintain general anesthesia was significantly lower for inhaled than for IV sevoflurane. |
| Databáze: | OpenAIRE |
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