| Autor: |
Jialiang Wang, Ethan Lee, R. Daniel Beauchamp, Stefan Knapp, Yan Guo, Emily E. Crispi, Lili Qin, Nan Tang, Sudan N. Loganathan, Leif R. Neitzel, Lihong Wang, Yufang Ma |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure 1. BET inhibition reduces MYC expression and MYC-dependent transcription; Supplementary Figure 2. BET inhibition impairs proliferation and survival of CRC cells; Supplementary Figure 3. Phosphorylation status of ERK in CRC cell lines; Supplementary Figure 4. BET inhibition sensitizes CRC cells to inhibitors of the MAPK pathway; Supplementary Figure 5. The combination of JQ1 and trametinib impairs colony formation in CRC cells; Supplementary Figure 6. Depletion of BRD4 sensitizes CRC cells to trametinib; Supplementary Figure 7. Knockdown of KRAS recapitulates the ability of MAPK pathway inhibitors to sensitize CRC cells to JQ1; Supplementary Figure 8. Response to JQ1 {plus minus} trametinib in DLD1 and derivative lines; Supplementary Figure 9. Response to JQ1 {plus minus} trametinib in RKO and derivative lines; Supplementary Figure 10. (A) MYC mRNA levels in RKO cells treated with 500 nmol/L JQ1 {plus minus} 50 nmol/L trametinib for 2 days; Supplementary Figure 11. Co-targeting of BET proteins and MEK effectively shifts expression of apoptotic regulators to promote apoptosis; Supplementary Figure 12. The combination of JQ1 and trametinib induced CRC xenograft tumor Regression; Supplementary Table 1. Real-time PCR primers used in this study; Supplementary Table 2. Genotypes and IC50 values for JQ1 and trametinib in CRC cell lines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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