Immunomodulation From Moderate Exercise Promotes Control of Experimental Cutaneous Leishmaniasis
| Autor: | Shayane Martins Rodrigues Gomes, P. M. L. Dutra, Verônica P. Salerno, Pedro J F Alves, Rodrigo Terra, Ana Karina Castro Lima, Luciana Silva Rodrigues, Silvia Amaral Gonçalves Da-Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Meglumine antimoniate 030106 microbiology Immunology lcsh:QR1-502 Leishmaniasis Cutaneous Physical exercise Microbiology Parasite load Parasite Load immune response lcsh:Microbiology Immunomodulation 03 medical and health sciences Immune system Cellular and Infection Microbiology Antigen Cutaneous leishmaniasis Physical Conditioning Animal Medicine Animals Leishmania major leishmaniasis Original Research control of infection Mice Inbred BALB C biology exercise business.industry Th1 Cells medicine.disease Leishmania biology.organism_classification Exercise Therapy Disease Models Animal 030104 developmental biology Infectious Diseases Treatment Outcome Balb/c Cytokines business medicine.drug |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 9 (2019) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2019.00115/full |
| Popis: | Physical exercise has been described as an important tool in the prevention and treatment of numerous diseases as it promotes a range of responses and adaptations in several biological systems, including the immune system. Studies on the effect of exercise on the immune system could play a critical role in improving public health. Current literature suggests that moderate intensity exercise can modulate the Th1/Th2 dichotomy directing the immune system to a Th1 cellular immune response, which favors the resolution of infections caused by intracellular microorganisms. Leishmaniasis is a group of diseases presenting a wide spectrum of clinical manifestations that range from self-limiting lesions to visceral injuries whose severity can lead to death. The etiological agents responsible for this group of diseases are protozoa of the genus Leishmania. Infections by the parasite Leishmania major in mice (Balb/c) provide a prototype model for the polarization of CD4+ T cell responses of both Th1 (resistance) or Th2 (susceptibility), which determines the progression of infections. The aim of this study was to evaluate the effect of exercise on the development of L. major experimental infections by scanning the pattern of immune response caused by exercise. Groups of Balb/c mice infected with L. major were divided into groups that preformed a physical exercise of swimming three times a week or were sedentary along with treatment or not with the reference drug, meglumine antimoniate. Animals in groups submitted to physical exercise did not appear to develop lesions and presented a significantly lower parasite load independent of drug treatment. They also showed a positive delayed hypersensitivity response to a specific Leishmania antigen compared to control animals. The IFN-γ/IL-4 and IFN-γ/IL10 ratios in trained animals were clearly tilted to a Th1 response in lymph node cells. These data suggest that moderate intensity exercise is able to modulate the Th1 response that provides a protective effect against the development of leishmanial lesions. |
| Databáze: | OpenAIRE |
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