Salience network glutamate and brain connectivity in medication-naïve first episode patients – A multimodal magnetic resonance spectroscopy and resting state functional connectivity MRI study
| Autor: | Adrienne C. Lahti, William Armstrong, Jose O. Maximo, Frederic Briend, Nina V. Kraguljac |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Psychosis
First episode psychosis Magnetic Resonance Spectroscopy Medication-naïve Cognitive Neuroscience Computer applications to medicine. Medical informatics R858-859.7 Posterior parietal cortex Glutamic Acid Glutamatergic Functional connectivity medicine Humans Radiology Nuclear Medicine and imaging RC346-429 Anterior cingulate cortex First episode Dorsal anterior cingulate Resting state fMRI business.industry Brain Regular Article medicine.disease Brain network Magnetic Resonance Imaging medicine.anatomical_structure Neurology Psychotic Disorders Schizophrenia Neurology (clinical) Neurology. Diseases of the nervous system Glutamate business Insula Neuroscience psychological phenomena and processes |
| Zdroj: | NeuroImage: Clinical, Vol 32, Iss, Pp 102845-(2021) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Highlights • The pathophysiology of salience network in schizophrenia remains poorly understood. • We found reduced connectivity, but no Glx alterations in psychosis patients. • The relationship between Glx and connectivity was abnormal in psychosis patients. • Findings suggest altered glutamatergic neurometabolism and connectivity in psychosis. Background Salience network (SN) connectivity is altered in schizophrenia, but the pathophysiological origin remains poorly understood. The goal of this multimodal neuroimaging study was to investigate the role of glutamatergic metabolism as putative mechanism underlying SN dysconnectivity in first episode psychosis (FEP) subjects. Methods We measured glutamate + glutamine (Glx) in the dorsal anterior cingulate cortex (dACC) from 70 antipsychotic-naïve FEP subjects and 52 healthy controls (HC). The dACC was then used as seed to define positive and negative resting state functional connectivity (FC) of the SN. We used multiple regression analyses to test main effects and group interactions of Glx and FC associations. Results dACC Glx levels did not differ between groups. Positive FC was significantly reduced in FEP compared to HC, and no group differences were found in negative FC. Group interactions of Glx-FC associations were found within the SN for positive FC, and in parietal cortices for negative FC. In HC, higher Glx levels predicted greater positive FC in the dACC and insula, and greater negative FC of the lateral parietal cortex. These relationships were weaker or absent in FEP. Conclusions Here, we found that positive FC in the SN is already altered in medication-naïve FEP, underscoring the importance of considering both correlations and anticorrelations for characterization of pathology. Our data demonstrate that Glx and functional connectivity work differently in FEP than in HC, pointing to a possible mechanism underlying dysconnectivity in psychosis. |
| Databáze: | OpenAIRE |
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