Celiac Disease Prevalence is Increased in Primary Sjögren's Syndrome and Diffuse Systemic Sclerosis: Lessons from a Large Multi-Center Study
| Autor: | Onelia Bistoni, Giulia Mirabelli, Marta Mosca, Alessia Alunno, Salvatore De Vita, Carlo Catassi, Francesco Carubbi, Roberto Giacomelli, Elena Bartoloni, Chiara Baldini, Andrea Doria, Roberto Gerli, Guido Valesini, Franco Franceschini, Armando Gabrielli, Colomba Fischetti, Vittorio Bini, Luca Quartuccio, Roberta Priori, Micaela Fredi, Linda Nalotto, Carlomaurizio Montecucco, Lorenzo Cavagna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Tissue transglutaminase systemic sclerosis Population Prevalence Lymphoproliferative disorders lcsh:Medicine Disease Gastroenterology Article Autoimmune thyroiditis 03 medical and health sciences 0302 clinical medicine systemic lupus erythematosus immune system diseases Internal medicine medicine education skin and connective tissue diseases Subclinical infection 030203 arthritis & rheumatology education.field_of_study biology business.industry lcsh:R General Medicine Sjögren’s syndrome autoimmune rheumatic diseases celiac disease Endomysium medicine.disease medicine.anatomical_structure biology.protein 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Clinical Medicine Volume 8 Issue 4 Journal of Clinical Medicine, Vol 8, Iss 4, p 540 (2019) |
| Popis: | Association of celiac disease (CD) with systemic autoimmune diseases (ADs) remains controversial. Awareness of CD in these patients is important to prevent complications, including lymphoproliferative disorders. We evaluated previously diagnosed CD prevalence in systemic lupus erythematosus (SLE), primary Sjö gren&rsquo s syndrome (pSS) and systemic sclerosis (SSc) patients in comparison to 14,298 matched controls. All patients were screened for subclinical CD. Data from 1458 unselected consecutive SLE (580), pSS (354) and SSc (524) patients were collected. Previously biopsy-proven CD diagnosis and both CD- and AD-specific features were registered. All patients without previous CD were tested for IgA transglutaminase (TG). Anti-endomysium were tested in positive/borderline IgA TG. Duodenal biopsy was performed in IgA TG/endomysium+ to confirm CD. CD prevalence in AD was compared to that observed in 14,298 unselected sex- and age-matched adults who acted as controls. CD was more prevalent in pSS vs controls (6.78% vs 0.64%, p < 0.0001). A trend towards higher prevalence was observed in SLE (1.38%, p = 0.058) and SSc (1.34%, p = 0.096). Higher CD prevalence was observed in diffuse cutaneous SSc (4.5%, p &le 0.002 vs controls). Subclinical CD was found in two SLE patients and one pSS patient. CD diagnosis usually preceded that of AD. Primary SS and SSc&ndash CD patients were younger at AD diagnosis in comparison to non-celiac patients. Autoimmune thyroiditis was associated with pSS and CD. CD prevalence is clearly increased in pSS and diffuse SSc in comparison to the general population. The association of CD with diffuse but not limited SSc may suggest different immunopathogenic mechanisms characterizing the two subsets. CD screening may be considered in pSS and diffuse SSc in young patients, particularly at the time of diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|