Initiation of atrial fibrillation by interaction of pacemakers with geometrical constraints
| Autor: | Martin Bauer, Frank Weber, Mario Einax, Philipp Maass, Gunnar Seeman, Claudia Lenk |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Statistics and Probability
medicine.medical_specialty Time Factors Refractory Period Electrophysiological Action Potentials General Biochemistry Genetics and Molecular Biology Heart Conduction System Internal medicine Atrial Fibrillation medicine Humans Computer Simulation Atrial electrophysiology Paroxysmal AF Fibrillation General Immunology and Microbiology Transmembrane voltage business.industry Applied Mathematics P wave Cardiac Pacing Artificial Models Cardiovascular Atrial fibrillation General Medicine medicine.disease Electrophysiology Phase coherence Modeling and Simulation Cardiology medicine.symptom General Agricultural and Biological Sciences business |
| Zdroj: | Journal of Theoretical Biology. 366:13-23 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2014.10.030 |
| Popis: | Atrial fibrillation (AF) is the most common arrhythmia of the heart in industrialized countries. Its generation and the transitory behavior of paroxysmal AF are still not well understood. In this work we examine the interaction of two activation sources via an isthmus as possible cause for the initiation of fibrillation episodes. For this study, the electrophysiological model of Bueno-Orovio, Cherry and Fenton is adapted to atrial electrophysiology, both for physiological and electrophysiologically remodeled conditions due to AF. We show that the interaction of the pacemakers, combined with the geometrical constraints of the isthmus, can produce fibrillatory-type irregularities, which we quantify by the loss of spatial phase coherence in the transmembrane voltage. Transitions to irregular behavior occur when the frequencies of the pacemakers exceed certain thresholds, suggesting that AF episodes are initiated by frequency changes of the activating sources (sinus node, ectopic focus). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect