A 3D view of how enteroviruses hijack autophagy

Autor:	Selma Dahmane, Kasturika Shankar, Lars-Anders Carlson
Rok vydání:	2022
Předmět:	Cell Biology Molecular Biology
Zdroj:	Autophagy.
ISSN:	1554-8635
Popis:	Viruses are masters at using cellular pathways to aid their replication. Cryo-electron tomography of poliovirus-infected cells revealed how it utilizes macroautophagy to its advantage. Assembly of these non-enveloped virions takes place directly on membranes and requires PIK3C3/VPS34 activity to be completed, whereas the canonical autophagy inducer ULK1 restricts virus assembly. The tomograms further revealed that enterovirus-induced autophagy is selective for RNA-loaded virions, which may help ensure maximum infectivity of the virus-laden vesicles released through secretory autophagy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c58a8880647cd85f1d96973352e5078 https://pubmed.ncbi.nlm.nih.gov/36471479 Zobrazit plný text záznamu