Polyphenolic Acetylcholinesterase Inhibitors from Hopea chinensis
| Autor: | Ren-Xiang Tan, Wei Wei, Hui Ming Ge, Tong Yan, Ting Wang, Yan Hua Qin, Nan Jiang |
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| Rok vydání: | 2012 |
| Předmět: |
Dipterocarpaceae
Magnetic Resonance Spectroscopy medicine.drug_class Stereochemistry Molecular Conformation Pharmaceutical Science Chemical Fractionation Pharmacognosy Analytical Chemistry Inhibitory Concentration 50 chemistry.chemical_compound Stilbenes Drug Discovery medicine Phenols Benzofurans Enzyme Assays Pharmacology Plant Stems Traditional medicine biology Organic Chemistry Computational Biology Polyphenols biology.organism_classification Acetylcholinesterase Hopea Hopea chinensis Complementary and alternative medicine chemistry Acetylcholinesterase inhibitor Resveratrol Polyphenol Plant Bark Molecular Medicine Cholinesterase Inhibitors |
| Zdroj: | Planta Medica. 78:1015-1019 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0031-1298623 |
| Popis: | Bioassay-guided investigation of the stem bark of Hopea chinensis led to the isolation of two new polyphenols, hopeachinols C (1) and D (2), together with ten known compounds (3–12). Compounds 1 and 2 were determined by extensive analysis of spectroscopic data and computational methods. All of these phytochemicals were tested for acetylcholinesterase inhibitory activity, and five resveratrol-derived compounds (1 and 7–10) exhibited significant activity with their IC50 values ranging from 4.81 to 11.71 µM. |
| Databáze: | OpenAIRE |
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