Synthetic approaches to 2-aryl/hetaryl- and 2-(hetaryl)ylidene derivatives of fluorinated 1,3-benzothiazin-4-ones
| Autor: | N. N. Mochul'skaya, Olga A. Batanova, Emiliya V. Nosova, Galina N. Lipunova |
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| Rok vydání: | 2020 |
| Předmět: |
1
3-benzothiazin-4-ones 2-fluorobenzoylchloride 2-fluorobenzoyl-isothiocyanate indole pyrrole cyanomethylbenzimidazole benzoylmethylbenzimidazole thioamide cyclocondensation tuberculostatics General Chemical Engineering chemistry.chemical_compound Materials Chemistry BENZOYLMETHYLBENZIMIDAZOLE QD1-999 Tuberculostatic Agents Thioamide 2‑FLUOROBENZOYLCHLORIDE Pyrrole Indole test chemistry.chemical_classification 1 3‑BENZOTHIAZIN-4‑ONES Aryl INDOLE 2‑FLUOROBENZOYL-ISOTHIOCYANATE CYANOMETHYLBENZIMIDAZOLE General Chemistry Combinatorial chemistry THIOAMIDE Chemistry chemistry CYCLOCONDENSATION PYRROLE TUBERCULOSTATICS |
| Zdroj: | Chimica Techno Acta, Vol 7, Iss 3, Pp 96-103 (2020) Chimica Techno Acta; Том 7, № 3 (2020); 96-103 |
| ISSN: | 2411-1414 2409-5613 |
| DOI: | 10.15826/chimtech.2020.7.3.01 |
| Popis: | Received: 28.06.2020. Accepted: 25.08.2020. Published: 07.10.2020. A series of 2‑hetaryl- and 2-(hetaryl)ylidene substituted 5‑fluoro-8‑nitro-1,3‑benzothiazin-4‑ones was synthesized by interaction of 2,6‑difluoro-3‑nitrobenzoylisothiocyanate with C-nucleophiles. Cyclocondensation of polyfluorobenzoylchlorides with aryl and hetaryl thioamides represents new approach to 1,3‑benzothiazin-4‑ones. Some compounds proved to be promising for further development of tuberculostatic agents. The work was carried out with financial support from the Ministry of Science and Higher Education of Russian Federation (project № FEUZ-2020–0058 (Н687.42Б.223/20)). |
| Databáze: | OpenAIRE |
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