Association of urinary 90 kDa angiotensin- converting enzyme with family history of hypertension and endothelial function in normotensive individuals
| Autor: | Dejaldo M. J. Christofalo, Marson O, Sergio Aron Ajzen, Fernanda Barrinha Fernandes, Maria do Carmo Franco, Andressa Melina Severino Teixeira, Frida Liane Plavnik, Ricardo Sesso, Dulce Elena Casarini |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP) |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Urinary system Immunology Biophysics Blood Pressure Ocean Engineering Peptidyl-Dipeptidase A Biochemistry Internal medicine Angiotensin-I-converting enzyme Humans Medicine Endothelial dysfunction General Pharmacology Toxicology and Pharmaceutics Family history biology business.industry General Neuroscience Angiotensin-converting enzyme Cell Biology General Medicine Angiotensin I converting enzyme Normotension N-domain angiotensin- converting enzyme Isoenzymes Endocrinology Case-Control Studies Blood circulation Blood Circulation Hypertension biology.protein Female Endothelium Vascular business Biomarkers |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1414-431X 0100-879X |
| DOI: | 10.1590/s0100-879x2008005000017 |
| Popis: | We described angiotensin-I-converting enzyme (ACE) isoforms with molecular masses of 190, 90, and 65 kDa in the urine of normotensive offspring of hypertensive subjects. Since they did not appear in equal amounts, we suggested that 90 kDa ACE might be a marker for hypertension. We evaluated the endothelial response in normotensive offspring with or without family history of hypertension and its association with the 90 kDa ACE in urine. Thirty-five normotensive subjects with a known family history of hypertension and 20 subjects without a family history of hypertension, matched for age, sex, body weight, and blood pressure, were included in the study. Endothelial function was assessed by ultrasound and a sample of urine was collected for determination of ACE isoforms. In the presence of a family history of hypertension and detection of 90 kDa ACE, we noted a maximal flow mediated dilation of 12.1 ± 5.0 vs 16.1 ± 6.0% in those without a previous history of hypertension and lacking urinary 90 kDa ACE (P < 0.05). In subjects with a family history of hypertension and presenting 90 kDa ACE, there were lower levels of HDL-cholesterol (P < 0.05) and higher levels of triglycerides (P < 0.05). Subjects with 90 kDa ACE irrespective of hypertensive history presented a trend for higher levels of triglycerides and HDL-cholesterol (P = 0.06) compared to subjects without 90 kDa ACE. Our data suggest that the 90 kDa ACE may be a marker for hypertension which may be related to the development of early atherosclerotic changes. Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina Fundação Oswaldo Ramos Universidade Federal de São Paulo (UNIFESP) e Hospital do Rim e Hipertensão Departamento de Radiologia UNIFESP, EPM, Depto. de Medicina Fundação Oswaldo Ramos UNIFESP, e Hospital do Rim e Hipertensão Depto. de Radiologia SciELO |
| Databáze: | OpenAIRE |
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