Regulation and Function of AQP4 in the Central Nervous System
| Autor: | Brian Roland Larsen, Nanna MacAulay, Mette Assentoft |
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| Rok vydání: | 2015 |
| Předmět: |
Aquaporin 4
Central Nervous System Water transport Central nervous system Water Aquaporin General Medicine Gating Biology Biochemistry Mice Cellular and Molecular Neuroscience medicine.anatomical_structure Astrocytes medicine Extracellular Animals Humans sense organs Neuroscience Function (biology) Astrocyte |
| Zdroj: | Neurochemical Research. 40:2615-2627 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-015-1519-z |
| Popis: | Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored. |
| Databáze: | OpenAIRE |
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