Inactivity of fecapentaene-12 as a rodent carcinogen or tumor initiator
| Autor: | Larry K. Keefer, Peter J. Donovan, L. Ohannesian, Noboru Konishi, S. Rehm, Jerry M. Rice, John R. Henneman, A.J. Streeter, T. Anjo, D.E. Devor, G.T. Smith, Elmer J. Reist, Jerrold M. Ward, Wallace W. Bradford |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Methylnitronitrosoguanidine Skin Neoplasms Ratón 9 10-Dimethyl-1 2-benzanthracene DMBA Colonic Polyps Mice Inbred Strains Polyenes Pharmacology chemistry.chemical_compound Mice medicine Animals Carcinogen Cocarcinogenesis Papilloma business.industry Rats Inbred Strains medicine.disease Rats Oncology chemistry Granuloma Tetradecanoylphorbol Acetate Carcinogens Female Pouch business Mutagens |
| Zdroj: | Cancer letters. 42(1-2) |
| ISSN: | 0304-3835 |
| Popis: | The possible carcinogenic activity of synthetic fecapentaene-12 (FP-12) was studied in several mammalian test systems: (a) for carcinogenicity by intrarectal instillation in male F344/NCr rats as well as by intrarectal and subcutaneous application in male B6C3F1 mice; (b) for initiation by skin painting in female SENCAR mice followed by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), with 7,12-dimethylbenz[a]anthracene (DMBA) followed by TPA as positive control; (c) in a rat subcutaneous granuloma pouch assay in which mutagenicity was measured by induction of 6-thioguanine (6-TG) resistance and carcinogenicity was determined by induction of subcutaneous tumors in the pouch. There was no significant increase in tumor incidence after 72-78 weeks in test (a), although 2 rats receiving FP-12 intrarectally developed colon polyps. FP-12 did not initiate any skin tumors in test (b), nor did it significantly convert DMBA-initiated papillomas into carcinomas when 8 of the positive control mice were given FP-12 weekly for 10 weeks after 10 weeks on the DMBA-TPA regimen. Although FP-12 and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were comparably mutagenic in test (c), FP-12 induced no tumors after more than a year in 133 rats at risk while MNNG induced 7 tumors in 107 rats. These rodent assays provide no evidence that FP-12 is a strong carcinogen, although the possibility remains that it may possess weak carcinogenic activity not revealed by these experiments. |
| Databáze: | OpenAIRE |
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