The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation
| Autor: | Helena Mora-Jensen, Anne Werner Hauge, Kit P. Lund, Søren Schwartz Sørensen, Frank Eriksson, Helle Bruunsgaard |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Genotype Immunology Disease Human leukocyte antigen Systemic inflammation 03 medical and health sciences 0302 clinical medicine HLA Antigens HLA-DR4 Antigen Immunology and Allergy Medicine Humans Kidney transplantation Retrospective Studies Inflammation Kidney business.industry Retrospective cohort study Middle Aged medicine.disease Phenotype Kidney Transplantation Transplantation 030104 developmental biology medicine.anatomical_structure Female medicine.symptom business Biomarkers 030215 immunology |
| Zdroj: | Web of Science |
| ISSN: | 1521-7035 |
| Popis: | The importance of the human leukocyte antigen (HLA) system in kidney transplantation is well-known, but it remains unexplored if patient HLA antigens constitute independent risk factors in complications after transplantation. We hypothesized that specific HLA class II phenotypes associated with immune-mediated disease (HLA-IMD) predispose to immunological activity and/or complications after kidney transplantation. Based on the literature we defined HLA-DR2-DQ6; -DR3-DQ2 and -DR4-DQ8 as HLA-IMD phenotypes. We investigated associations between HLA-IMD phenotypes in patients, biomarkers of systemic chronic inflammation at the time of transplantation, and the outcome after kidney transplantation in a retrospective cohort study of 611 kidney transplanted patients. The HLA-IMD phenotypes were associated with higher levels of biomarkers of systemic inflammation. The HLA-DR4-DQ8 phenotype was associated with mortality after transplantation in Cox analyses with adjustments for confounders. Data support the hypothesis that specific HLA class II phenotypes affects immunological pathways that determine the midterm clinical outcome of kidney transplantation. |
| Databáze: | OpenAIRE |
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