Intranasal mucoadhesivemicroemulsion for neuroprotective effect of curcuminin mptp induced Parkinson model
| Autor: | Jayvadan Patel, Snigdha Das Mandal, Surjyanarayan Mandal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Sodium hyaluronate
lcsh:RS1-441 Response surface methodology (RSM) Pharmacology Parkinson's disease/treatment 030226 pharmacology & pharmacy Neuroprotection Male mice C57BL/6 Open field lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Curcumin/neuroprotective effect Dopamine Neurodegradation Medicine General Pharmacology Toxicology and Pharmaceutics business.industry MPTP Dopaminergic chemistry Anesthesia Curcumin Nasal administration Box-Behnken design business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017) Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e15223 Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e15223 Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e15223 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Pharmaceutical Sciences, Volume: 53, Issue: 2, Article number: e15223, Published: 22 JUN 2017 |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | This study was to investigate the neuroprotective effect of curcumin against inflammation-mediated dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD). Curcumin loaded sodium hyaluronate based mucoadhesive microemulsion (CMME) was developed by using Box Behnken design of Response surface method (RSM) and was characterized. Male C57BL/6 mice were first treated with four intraperitoneal injections of MPTP (20 mg/kg of body weight) at 2 h intervals followed CMME intranasal administration for 14 days at 2.86 mg of curcumin/kg of body weight per once a day. Optimal CMME containing 3% Capmul MCM as oil phase, 37 % of Accenon CC and Transcutol HP at 2.5:1 ratio and 0.5% sodium hyaluronate was stable, non-ciliotoxic with 57.66 nm±3.46 as average globule size. PdI value (0.190 ± 0.19) and TEM result depicted the narrow size distribution of CMME.All three independent variables had a significant effect (p |
| Databáze: | OpenAIRE |
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