Vitamin D3metabolites in amniotic fluid in relation with maternal and fetal sera in term pregnancies
| Autor: | Gideon Kidroni, Lydia Schwartz, Zvi Palti, Moshe Ron, Jaccob Menczel |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Vitamin
medicine.medical_specialty Cord Amniotic fluid 24 25-Dihydroxyvitamin D 3 Metabolite education chemistry.chemical_compound Calcitriol Pregnancy Internal medicine Vitamin D and neurology Humans Medicine Calcifediol Fetus business.industry Obstetrics and Gynecology Amniotic Fluid Fetal Blood medicine.disease Endocrinology chemistry Pediatrics Perinatology and Child Health Dihydroxycholecalciferols Female business Cholecalciferol |
| Zdroj: | Journal of Perinatal Medicine. 15:282-290 |
| ISSN: | 1619-3997 0300-5577 |
| Popis: | The concentration of 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) were determined in amniotic fluid, fetal cord serum and maternal serum in 26 cases of elective cesarean sections at term. All the women had a normal pregnancy and did not get any vitamin D fortified preparations. The samples were collected during December 1982-April 1983, at 37-40 weeks of pregnancy. The respective levels (+/- S.D.) of 25(OH)D3, 24,25(OH)2D3 and 1,25(OH)2D3 in maternal serum were: 18.03 +/- 10.8 ng/ml, 1.473 +/- 1.562 ng/ml and 36 +/- 21.5 pg/ml; in fetal cord serum: 13.15 +/- 8.3 ng/ml, 0.9 +/- 0.76 ng/ml and 29.2 +/- 18.55 pg/ml and in amniotic fluid: 0.732 +/- 0.508 ng/ml, 0.212 +/- 0.104 ng/ml and 14.3 +/- 10.0 pg/ml. The levels of the three metabolites in maternal and fetal cord serum were not statistically different. There was a statistically significant correlation between maternal and fetal serum levels of 25(OH)D3 and 24,25(OH)2D3 (r = 0.79, p less than 0.01 and r = 0.743, p less than 0.01 respectively). No significant correlation was found in 1,25(OH)2D3 levels between maternal and fetal cord sera. This lack of correlation may well be in agreement with the recent findings of Kouppala, et al. who demonstrated that the fetus contributes to its own pool of 1,25(OH)2D3. A significant difference was found between maternal serum and amniotic fluid levels of the three metabolites. A statistically significant difference was also found between fetal serum levels of 25(OH)D3 and 24,25(OH)2D3 and amniotic fluid levels.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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