Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas

Autor: Gry Kvalheim, Henk J. Blom, Øivind Midttun, Akke Botma, Audrey Y. Jung, Ellen Kampman, Carolien Lute, Per Magne Ueland, Wilma T. Steegenga, Fokko M. Nagengast
Přispěvatelé: Clinical chemistry, ICaR - Circulation and metabolism, CCA - Innovative therapy
Rok vydání: 2012
Předmět:
Male
Nutrition and Disease
Colorectal cancer
human methylenetetrahydrofolate reductase
Voeding
Metabolisme en Genomica
chemistry.chemical_compound
Methionine
Risk Factors
common mutation
moderate folate-depletion
Voeding en Ziekte
Surveys and Questionnaires
Genotype
liquid-chromatography
Leukocytes
tandem mass-spectrometry
folic-acid
microbiological assay
Human Nutrition & Health
Humane Voeding & Gezondheid
Methylation
Middle Aged
Metabolism and Genomics
risk-factor
Metabolisme en Genomica
DNA methylation
Vitamin B Complex
Nutrition
Metabolism and Genomics
Female
Colorectal Neoplasms
colon-cancer
Biotechnology
Adenoma
Adult
medicine.medical_specialty
Adolescent
Colorectal adenoma
Biology
Young Adult
Folic Acid
Voeding
Internal medicine
medicine
Humans
Risk factor
Life Style
Methylenetetrahydrofolate Reductase (NADPH2)
Nutrition
Molecular epidemiology Aetiology
screening and detection [NCEBP 1]
VLAG
Aged
DNA Methylation
one-carbon metabolism
medicine.disease
B vitamins
Endocrinology
Cross-Sectional Studies
Long Interspersed Nucleotide Elements
chemistry
Multivariate Analysis
Linear Models
Food Science
Follow-Up Studies
Zdroj: Jung, A Y, Botma, A, Lute, C, Blom, H J, Ueland, P M, Kvalheim, G, Midttun, O, Nagengast, F, Steegenga, W & Kampman, E 2013, ' Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas ', Molecular Nutrition and Food Research, vol. 57, no. 4, pp. 698-708 . https://doi.org/10.1002/mnfr.201200069
Molecular Nutrition & Food Research, 57(4), 698-708
Molecular Nutrition & Food Research (Formerly Nahrung/Food), 57, 4, pp. 698-708
Molecular Nutrition & Food Research 57 (2013) 4
Molecular Nutrition and Food Research, 57(4), 698-708. Wiley-VCH Verlag
Molecular Nutrition & Food Research (Formerly Nahrung/Food), 57, 698-708
ISSN: 1613-4133
1613-4125
DOI: 10.1002/mnfr.201200069
Popis: Item does not contain fulltext SCOPE: Low concentrations of folate, other B vitamins, and methionine are associated with colorectal cancer risk, possibly by changing DNA methylation patterns. Here, we examine whether plasma concentrations of B vitamins and methionine are associated with methylation of long interspersed nuclear element-1 (LINE-1) among those at high risk of colorectal cancer, i.e. patients with at least one histologically confirmed colorectal adenoma (CRA) in their life. METHODS AND RESULTS: We used LINE-1 bisulfite pyrosequencing to measure global DNA methylation levels in leukocytes of 281 CRA patients. Multivariable linear regression was used to assess associations between plasma B vitamin concentrations and LINE-1 methylation levels. Plasma folate was inversely associated with LINE-1 methylation in CRA patients, while plasma methionine was positively associated with LINE-1 methylation. CONCLUSION: This study does not provide evidence that in CRA patients, plasma folate concentrations are positively related to LINE-1 methylation in leukocytes but does suggest a direct association between plasma methionine and LINE-1 methylation in leukocytes.
Databáze: OpenAIRE
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