Brain regions susceptible to alpha-synuclein spreading
| Autor: | Kang Chen, Jin-Jun Zou, Huan Xiong, Yu-jie Guo, Peng Lei |
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| Rok vydání: | 2021 |
| Předmět: |
Alpha-synuclein
Postmortem studies Cell type Motor dysfunction Synucleinopathies Drug discovery animal diseases Brain Parkinson Disease Disease Biology nervous system diseases Disease Models Animal Cellular and Molecular Neuroscience Psychiatry and Mental health chemistry.chemical_compound Animal model nervous system chemistry alpha-Synuclein health occupations Animals heterocyclic compounds Molecular Biology Neuroscience |
| Zdroj: | Molecular Psychiatry. 27:758-770 |
| ISSN: | 1476-5578 1359-4184 |
| Popis: | The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal models of Parkinson's disease (PD) and other α-synucleinopathies that mimic human PD pathologies. In animal models, the spreading of α-syn has been associated with motor dysfunction and neuronal death. However, variability in both susceptible brain regions and cellular populations limits our understanding of the consequences of α-syn spreading and the development of associated therapies. Here, we have reviewed the physiological and pathological functions of α-syn and summarized the susceptible brain regions and cell types identified from human postmortem studies and exogenous α-syn injection-based animal models. We have reviewed the methods for inducing α-syn aggregation, the specific hosts, the inoculation sites, the routes of propagation, and other experimental settings that may affect the spreading pattern of α-syn, as reported in current studies. Understanding the spread of α-syn to produce a consistent PD animal model is vital for future drug discovery. |
| Databáze: | OpenAIRE |
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