Adjuvant Chemotherapy after Neoadjuvant Chemotherapy and Long-term Outcomes of CAPOX Plus Bevacizumab Followed by TME for High-risk Localized Rectal Cancer
| Autor: | Tatsushi Shingai, Mamoru Uemura, Takamichi Komori, Taishi Hata, Masaki Tsujie, Tsunekazu Mizushima, Kimimasa Ikeda, Junichi Nishimura, Masayoshi Yasui, Keigo Yasumasa, Masataka Ikeda, Yuichiro Doki, Masaki Mori, Shingo Noura, Chu Matsuda, Junichi Hasegawa |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
bevacizmab medicine.medical_specialty Chemotherapy Bevacizumab Adjuvant chemotherapy business.industry Colorectal cancer medicine.medical_treatment medicine.disease Oxaliplatin Capecitabine Regimen CapeOX Internal medicine medicine lcsh:Diseases of the digestive system. Gastroenterology Original Research Article lcsh:RC799-869 rectal cancer Prospective cohort study business long-term survival neoadjuvant chemotherapy medicine.drug |
| Zdroj: | Journal of the Anus, Rectum and Colon Journal of the Anus, Rectum and Colon, Vol 4, Iss 3, Pp 108-113 (2020) |
| ISSN: | 2432-3853 |
| DOI: | 10.23922/jarc.2019-042 |
| Popis: | Objectives We previously reported the feasibility of neoadjuvant capecitabine and oxaliplatin plus bevacizumab as a treatment for locally advanced rectal cancer (UMIN000003219). The aim of this study is to investigate the prognostic relevance of neoadjuvant chemotherapy followed by total mesorectal resection (TME). Methods Twenty-five patients of our prior multicenter prospective study of neoadjuvant chemotherapy followed by TME enrolled to this study. We analyzed the adjuvant chemotherapy regimen, and the duration between surgery and initial chemotherapy treatment. Five-year progression-free survival and overall survival were estimated using the Kaplan-Meier method. Results Among survivors, the median follow-up time was 66 months. Recurrence occurred in six patients, all of whom had suboptimal tumor regression after neoadjuvant chemotherapy. Five patients died from other causes. The rate of local recurrence and distant metastasis was 17.4% and 8.7%, respectively. Five-year progression-free survival was 70.0%, and 5 year overall survival was 84.0%. Conclusions We report the long-term survival of patients who received neoadjuvant chemotherapy without radiation followed by TME, revealing a generally favorable prognosis. |
| Databáze: | OpenAIRE |
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