The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats
| Autor: | Mehmet Yilmaz, Sanli Sadi Kurdak, Özgür Günaşti, Hale Oksuz, Kerem T. Özgünen, Suzan Zorludemir, Çiğdem Özdemir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Calorie Physiology Biophysics Citrate (si)-Synthase Mitochondrion Lipid droplet Internal medicine Animals Citrate synthase Medicine Aerobic exercise RNA Messenger Carnitine Muscle Skeletal Carnitine O-Palmitoyltransferase biology business.industry Myocardium Cardiac muscle Skeletal muscle General Medicine Rats Endocrinology medicine.anatomical_structure biology.protein business medicine.drug |
| Zdroj: | General physiology and biophysics. 40:341-350 |
| ISSN: | 1338-4325 |
| DOI: | 10.4149/gpb_2021019 |
| Popis: | In this study, the effect of high-calorie feeding and aerobic exercise on skeletal and cardiac muscle citrate synthase (CS), carnitine palmitoyltransferase-I (CPT-I), and -II (CPT-II) mRNA expressions were evaluated. Genetically non-obese rats were grouped as normal-high calorie and sedentary-exercising. Gastrocnemius-soleus and heart muscles' CS, CPT-I, and CPT-II expressions and skeletal muscles' histopathological characteristics were evaluated. High-fat diet had increased body weight by 10% and aerobic exercise did not make any difference. Skeletal muscle CS expression was increased significantly in normal-calorie exercising group. Exercise and high-fat diet did not change CPT-I and CPT-II expressions in both heart and skeletal muscle. Histopathological evaluations demonstrated increased cytoplasmic lipid droplets in high-calorie fed sedentary rats, and exercise had reduced lipid droplets in skeletal muscle. Also, both mitochondria and nuclei distribution were impaired in high-calorie groups. In conclusion, aerobic exercise without food restriction was not enough to make significant changes in fat transportation mechanism into skeletal and heart muscle. |
| Databáze: | OpenAIRE |
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