Surgery and post-operative radiotherapy for early stage cervical cancer
| Autor: | Jonathan Carter, Peter Elliott, Shalini K Vinod, Craig MacLeod, K. Atkinson, Ian Firth, Christopher Dalrymple |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Adenocarcinoma Hysterectomy Disease-Free Survival Carcinoma Adenosquamous medicine Humans Postoperative Period Stage (cooking) Survival analysis Aged Retrospective Studies Aged 80 and over Cervical cancer business.industry Incidence (epidemiology) Obstetrics and Gynecology Retrospective cohort study General Medicine Middle Aged medicine.disease Survival Analysis Surgery Radiation therapy Carcinoma Squamous Cell Female Radiotherapy Adjuvant New South Wales business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1479-828X 0004-8666 |
| DOI: | 10.1111/j.1479-828x.2000.tb03170.x |
| Popis: | The use of post-operative radiotherapy in the treatment of cervical cancer is controversial. The aim of this study was to document the results and toxicity of adjuvant irradiation in patients with Stage 1B and 2A cervical cancer. We performed a retrospective review of all patients treated with post-operative radiotherapy at Royal Prince Alfred Hospital between 1986 and 1993. Patient, tumour and treatment factors and late toxicity were recorded. Relapse-free and overall survival were calculated. Eighty-one patients form the study population. The median follow-up was 6.1 years. Fifty-eight patients (72%) had stage 1B cervical cancer and 23 (28%) stage 2A. The 5 year relapse-free and overall survival were 78% and 80% respectively. Six patients (7%) had late toxicity requiring inpatient medical treatment and 6 patients (7%) required surgery. The survival was comparable to other series reported in the literature. There was an incidence of 14% late toxicity requiring medical or surgical intervention which is greater than with hysterectomy or pelvic irradiation alone. Clinical prognostic factors should be used to select patients for either surgery or radiotherapy alone to minimise the increased toxicities associated with a combination of surgery and radiotherapy. |
| Databáze: | OpenAIRE |
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