Interaction of aspirin (acetylsalicylic acid) with lipid membranes
| Autor: | Chris Huynh, Songbo Zheng, Maikel C. Rheinstädter, Matthew A. Barrett, Randy K. R. Belanger, Richard J. Alsop, Norbert Kučerka, Golnaz Roshankar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Macromolecular Assemblies
Lipid Bilayers lcsh:Medicine Biochemistry 01 natural sciences Cell membrane chemistry.chemical_compound X-Ray Diffraction Drug Interactions Lipid bilayer phase behavior Lipid bilayer lcsh:Science 0303 health sciences Multidisciplinary Physics Electromagnetic Radiation Bilayer 16. Peace & justice Lipids Cholesterol medicine.anatomical_structure Membrane Cytochemistry Medicine lipids (amino acids peptides and proteins) Dimyristoylphosphatidylcholine Hydrophobic and Hydrophilic Interactions Research Article Drugs and Devices Biophysics Phospholipid Electrons 010402 general chemistry Membrane Structures 03 medical and health sciences Lipid Structure medicine Molecule Biology 030304 developmental biology Aspirin X-Rays Cell Membrane lcsh:R Lipid Aggregates 0104 chemical sciences chemistry lcsh:Q Membrane Composition |
| Zdroj: | PLoS ONE, Vol 7, Iss 4, p e34357 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | We studied the interaction of Aspirin (acetylsalicylic acid) with lipid membranes using x-ray diffraction for bilayers containing up to 50 mol% of aspirin. From 2D x-ray intensity maps that cover large areas of reciprocal space we determined the position of the ASA molecules in the phospholipid bilayers and the molecular arrangement of the molecules in the plane of the membranes. We present direct experimental evidence that ASA molecules participate in saturated lipid bilayers of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) and preferably reside in the head group region of the membrane. Up to 50 mol% ASA molecules can be dissolved in this type of bilayer before the lateral membrane organization is disturbed and the membranes are found to form an ordered, 2D crystal-like structure. Furthermore, ASA and cholesterol were found to co-exist in saturated lipid bilayers, with the ASA molecules residing in the head group region and the cholesterol molecules participating in the hydrophobic membrane core. |
| Databáze: | OpenAIRE |
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