Intramedullary pilomyxoid astrocytoma with intracerebral metastasis exhibiting oligodendroglioma-like features
| Autor: | Hendrik Janssen, Sabina Eigenbrod, Hans A. Kretzschmar, Christian la Fougère, Rupert Egensperger, Aurelia Peraud, Nathalie Jansen, Michael Ruiter, Janina Mielke, Niklas Thon |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pilomyxoid astrocytoma
Pathology medicine.medical_specialty Histology Intramedullary glioma Case Report lcsh:RC254-282 law.invention Metastasis Intramedullary rod law Glioma Female patient medicine metastasis 1p19q Pathological Heterogeneous group business.industry medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tumor recurrence Oncology pilomyxoid astrocytoma business |
| Zdroj: | Rare Tumors, Vol 4, Iss 2, Pp e30-e30 (2012) Rare Tumors |
| ISSN: | 2036-3613 2036-3605 |
| Popis: | Intramedullary glioma are rare and their biological behaviour can differ from their cerebral counterparts. Pilomyxoid astrocytoma (PMA, WHO grade II), predominantly occur in the hypothalamic/chiasmatic region of infants and children. The few reported cases of pediatric intramedullary PMA displayed a particularly aggressive behavior. Here, we report a diagnostically challenging case of a five year old female patient presenting with intramedullary glioma and local tumor recurrence three years later. Twelve years after the initial manifestation, a second tumor was found intracerebrally. We performed a comprehensive histological, molecular pathological and imaging analysis of the tumors from both localizations. The results revealed a metastasizing PMA with unique histological and genetic features. Our study indicates that PMA comprise a heterogeneous group including aggressive subtypes which may not be compatible with the current classification according to WHO grade II. Furthermore, the case emphasizes the increasing relevance of molecular pathological markers complementing classic histo-logical diagnosis. |
| Databáze: | OpenAIRE |
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