Spindle orientation: a question of complex positioning
| Autor: | Daniel St Johnston, Nicole S Dawney, Daniel T. Bergstralh |
|---|---|
| Přispěvatelé: | Bergstralh, Dan T [0000-0003-1689-3715], Apollo - University of Cambridge Repository |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell division Spindle Apparatus Biology GTP-Binding Protein alpha Subunits Gi-Go Microtubules Models Biological Spindle pole body 03 medical and health sciences 0302 clinical medicine Microtubule Asymmetric cell division Animals Humans Molecular Biology Metaphase Cell Shape fungi Mitotic spindle Spindle orientation Spindle apparatus Cell biology 030104 developmental biology Stem cell division Astral microtubules 030217 neurology & neurosurgery Cell Division Developmental Biology |
| DOI: | 10.17863/cam.46499 |
| Popis: | The direction in which a cell divides is determined by the orientation of its mitotic spindle at metaphase. Spindle orientation is therefore important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. In multiple cell types in multiple animals, spindle orientation is controlled by a conserved biological machine that mediates a pulling force on astral microtubules. Restricting the localization of this machine to only specific regions of the cortex can thus determine how the mitotic spindle is oriented. As we review here, recent findings based on studies in tunicate, worm, fly and vertebrate cells have revealed that the mechanisms for mediating this restriction are surprisingly diverse. |
| Databáze: | OpenAIRE |
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