Impact of AJCC 8 pT staging in cutaneous head and neck squamous cell carcinoma in a nonselected real-world patient sample

Autor:	Fábio Muradás Girardi, Vivian P. Wagner, Manoela Domingues Martins, Aliende Lengler Abentroth, Luiz Alberto Hauth
Rok vydání:	2022
Předmět:	Otorhinolaryngology
Zdroj:	HeadneckREFERENCES. 45(2)
ISSN:	1097-0347
Popis:	Our aim was to evaluate characteristics associated with worse survival and the effectiveness of AJCC 8 in a real-world cohort of HNCSCC from South Brazil.A 10-year retrospective cohort study (2011-2020) at a tertiary care center comprising 647 HNCSCC excised from 435 patients.At multivariable analysis, ear/nose/zygomatic or periorbital site, compromised or exiguous margins, and advanced pT stage were independent factors associated to DFS, while age, pN, and loco-regional recurrence were independent factors associated to DSS. Cox-regression multivariable models showed that the pT stage was statistically significant for the DFS, but not DSS. A significant distinction was only observed between T1 and T2.It was only in the lower categories of AJCC 8 (T1 and T2) that we were able to demonstrate the ability to stratify tumors with a significant risk of poor disease-related outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c429962342feaaed9cbebacb3f91cb9 https://pubmed.ncbi.nlm.nih.gov/36345615 Zobrazit plný text záznamu Plný text