Genomic Variation of the Fibropapilloma-Associated Marine Turtle Herpesvirus across Seven Geographic Areas and Three Host Species
| Autor: | James W. Casey, Rufina N. Casey, Sandra L. Quackenbush, Joel Rovnak, Claudia A. Sutton, George H. Balazs, Thierry M. Work, Rebecca J. Greenblatt |
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| Rok vydání: | 2005 |
| Předmět: |
Fibropapillomatosis
Molecular Sequence Data Immunology Zoology Lepidochelys olivacea Fibroma medicine.disease_cause Microbiology Genome Virus Virology Alphaherpesvirinae medicine Animals Amino Acid Sequence Letters to the Editor Herpesviridae Phylogeny Base Sequence Papilloma biology Contig Ecology Nucleic acid sequence Genetic Variation biology.organism_classification Turtles Herpes simplex virus Insect Science Recombination and Evolution |
| Zdroj: | Journal of Virology. 79:1125-1132 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.79.2.1125-1132.2005 |
| Popis: | Fibropapillomatosis (FP) of marine turtles is an emerging neoplastic disease associated with infection by a novel turtle herpesvirus, fibropapilloma-associated turtle herpesvirus (FPTHV). This report presents 23 kb of the genome of an FPTHV infecting a Hawaiian green turtle ( Chelonia mydas ). By sequence homology, the open reading frames in this contig correspond to herpes simplex virus genes U L 23 through U L 36. The order, orientation, and homology of these putative genes indicate that FPTHV is a member of the Alphaherpesvirinae . The U L 27-, U L 30-, and U L 34-homologous open reading frames from FPTHVs infecting nine FP-affected marine turtles from seven geographic areas and three turtle species ( C. mydas , Caretta caretta , and Lepidochelys olivacea ) were compared. A high degree of nucleotide sequence conservation was found among these virus variants. However, geographic variations were also found: the FPTHVs examined here form four groups, corresponding to the Atlantic Ocean, West pacific, mid-Pacific, and east Pacific. Our results indicate that FPTHV was established in marine turtle populations prior to the emergence of FP as it is currently known. |
| Databáze: | OpenAIRE |
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