Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
| Autor: | Cristina Cereda, Jurjen J. Luykx, Sandra Meier, Derek W. Morris, Douglas M. Ruderfer, Mythily Subramaniam, Paul Cormican, Lyudmila Georgieva, John Landers, Silvana Penco, Marian L. Hamshere, Frank Dudbridge, Mari Nelis, Dick Schijven, Jimmy Lee, Sarah E. Bergen, Alessandro Padovani, Nicholas W. Wood, Meraida Polak, Hannelore Ehrenreich, Nancy G. Buccola, Noa Carrera, Stefan Herms, Panos Roussos, Marion Friedl, Teimuraz Silagadze, Jim van Os, Annette M. Hartmann, Ole A. Andreassen, R. Jeroen Pasterkamp, Sibylle G. Schwab, Aleksey Shatunov, Eli A. Stahl, David A. Collier, Farooq Amin, Michael Conlon O'Donovan, Guiqing Cai, Kung-Yee Liang, Denis C. Bauer, Charles Curtis, Brion S. Maher, Ashley R. Jones, Sara L. Pulit, Sarah Tosato, Milan Macek, Vivianna M. Van Deerlin, Vincenzo Silani, Pietro Fratta, Bettina Konte, Rosanna Tortelli, Dan Rujescu, T. Scott Stroup, Elizabeth Bevilacqua, Christian Lunetta, Bradley T. Webb, Christophe Tzourio, Patrick Vourc'h, Joel N. Hirschhorn, Gilbert Bensimon, Timothy G. Dinan, Thomas G. Schulze, Richard A. Belliveau, Daniel R. Weinberger, Andrew McQuillin, Qingqin S. Li, Orla Hardiman, Claudine Laurent, Masashi Ikeda, Tim Kahlke, Rodney J. Scott, Frans Henskens, Tune H. Pers, Wolfgang Lieb, Christian Hammer, Elvira Bramon, Hana Kuzelova-Ptackova, Raquelle I. Mesholam-Gately, Ingrid Melle, Nadine Cohen, David Cohen, Nazli Basak, Elisabeth Stögmann, Nelson B. Freimer, Peter Eichhammer, J. Mallet, Preben Bo Mortensen, Robert H. Brown, Wouter van Rheenen, Roberto Del Bo, Dai Wang, Laurent Essioux, Larry J. Seidman, Hreinn Stefansson, Erik G. Jönsson, Mads V. Hollegaard, Raymond C.K. Chan, Susana Pinto, Alexander Richards, Jubao Duan, Peter Holmans, George Kirov, Pablo V. Gejman, Philippe Amouyel, Stephanie Godard, Dieter B. Wildenauer, Martina Wiedau-Pazos, Stacy Steinberg, Ole Mors, Andres Metspalu, Rolf Adolfsson, Shaun Purcell, Hugh Gurling, Joseph I. Friedman, Erik Söderman, Mark Weiser, Giacomo P. Comi, James A. Knowles, Peter M. Andersen, Brien P. Riley, Nakao Iwata, Jeremy M. Silverman, Mark J. Daly, Elena Parkhomenko, Digby Quested, Srinivas Thirumalai, Ulrich Schall, Jan Lubinski, Dragan M. Svrakic, Aaron R. Wolen, S. Hong Lee, Andrew Pocklington, Bernard Lerer, Vahram Haroutunian, Matthew C. Kiernan, Kenneth L. Davis, Assen Jablensky, William Byerley, Karol Estrada, Aarno Palotie, Cinzia Tiloca, Eadbhard O'Callaghan, Perry T.C. van Doormaal, Colm McDonald, Federico Casale, Thomas Meitinger, Robert Freedman, Gerome Breen, Milena Blagojevic-Radivojkov, Ian P. Blair, Ann E. Pulver, Jan H. Veldink, Giancarlo Logroscino, Miaoxin Li, Abraham Reichenberg, Esben Agerbo, Siddharthan Chandran, Patrik K. E. Magnusson, Andrew M. McIntosh, Gianni Sorarù, Maura Brunetti, Xuebin Zheng, Madeline Alexander, James L. Kennedy, Douglas Blackwood, Menachem Fromer, Martilias S. Farrell, Alan R. Sanders, Dominic B. Rowe, Alexis Brice, Jonathan Pimm, Emily H. M. Wong, Jana Strohmaier, André G. Uitterlinden, Andrea Calvo, Carsten Drepper, John Q. Trojanowski, Marcella Rietschel, Siow Ann Chong, Karen E. Morrison, Sang-Yun Oh, Laura Nisenbaum, Margaret O'Brien, Alkes L. Price, Carin J. Meijer, Michael Davidson, John Powell, Petr Slominsky, Wiepke Cahn, Cinzia Gellera, Vihra Milanova, Peter M. Visscher, Patricia T. Michie, Dimitris Dikeos, Jianxin Shi, Veikko Salomaa, Philip Van Damme, James J. Crowley, Younes Mokrab, Valentina Escott-Price, Jesus S. Mora, Stanley V. Catts, David St Clair, Bernhard Landwehrmeyer, John Hardy, Kristin K. Nicodemus, Dominique Campion, Juha Veijola, Wim Robberecht, Thomas Meyer, Peter Lichtner, Christos Pantelis, Markus Weber, Nilo Riva, Jin P. Szatkiewicz, Michele T. Pato, Cinzia Bertolin, Frank P. Diekstra, Simon Arcuti, Bryan J. Mowry, Hon-Cheong So, Adriano Chiò, Viviana Pensato, Yunjung Kim, Jean-François Dartigues, Zita Ausrele Kucinskiene, Inez Myin-Germeys, Jaana Suvisaari, Sophie E. Legge, Roel A. Ophoff, Philippe Corcia, Gerald Nestadt, Stephan Ripke, Kuang Lin, Paola Giusti-Rodríguez, Michael John Owen, Chris C. A. Spencer, Safa Saker-Delye, Robert W. McCarley, Kimberley D. Chambert, Brandon Wormley, Isabella Fogh, Mamede de Carvalho, Pamela J. Shaw, Tõnu Esko, Ronald Y. L. Chan, Jianjun Liu, Tim B. Bigdeli, Christian R. Andres, David M. Hougaard, Michael Gill, Ammar Al-Chalabi, Colm O'Dushlaine, Rick A.A. van der Spek, Gary Donohoe, Tao Li, Jonathan D. Glass, Christopher Shaw, Draga Toncheva, Leonard H. van den Berg, Liene Nikitina-Zake, Morten Mattingsdal, François Salachas, Andrey Khrunin, Line Olsen, Jochen H. Weishaupt, Jo Knight, Katie Sidle, Filip Eftimov, Massimiliano Filosto, Russell L. McLaughlin, Pak C. Sham, Joshua L. Roffman, Thomas Hansen, Naser Durmishi, Deborah A. Nertney, Juha Karjalainen, Robert Swingler, Ditte Demontis, Vaidutis Kučinskas, Jennifer L. Moran, Leo McCluskey, Donald W. Black, Eric F.C. Cheung, Qiang Wang, Olli Pietilainen, Vera Golimbet, Anna K. Kähler, Clement C. Zai, Nigel Williams, Annelie Nordin, Wolfgang Maier, Bradley N. Smith, Ettore Beghi, Rosa Capozzo, Garth A. Nicholson, Markus M. Nöuthen, Jordan W. Smoller, Eric Y.H. Chen, Joseph D. Buxbaum, Letizia Mazzini, Andrea Malaspina, Antonio Julià, Stephanie Williams, Tracey L. Petryshen, Christine Payan, Johan G. Eriksson, Carmel M. Loughland, Elodie Drapeau, Lieuwe de Haan, Martin Begemann, Lukas Tittmann, Franziska Degenhardt, Mark Reimers, Jurgen Del Favero, Jacqueline I. Goldstein, Annelot M. Dekker, Sergi Papiol, Svetlana A. Limborska, René S. Kahn, Shuna Colville, Kelly L. Williams, Pamela Sklar, Diana O. Perkins, Lili Milani, Ayman H. Fanous, Nicola Ticozzi, Fernando Rivadeneira, Marianne de Visser, P. Nigel Leigh, James T.R. Walters, Josef Frank, Aiden Corvin, Silviu Alin Bacanu, John L. Waddington, Stephanie H. Witt, Tiina Paunio, Margot Albus, Catherine Lomen-Hoerth, Sara Marsal, Per Hoffmann, David Curtis, Cindy Maurel, Todd Lencz, Orietta Pansarasa, Manuel Mattheisen, Anneke J. van der Kooi, A. Hofman, Dermot Walsh, Hailiang Huang, Ann Olincy, Anders D. Børglum, Ricardo Rojas-García, William Sproviero, Albert C. Ludolph, Edward M. Scolnick, Danielle Posthuma, George N. Papadimitriou, Michael A. van Es, Fritz Zimprich, F. Anthony O'Neill, Lude Franke, Jouko Lönnqvist, Daniel G. Bradley, Sven Cichon, Susanna Abdulla, Kristel R. van Eijk, Ingrid Agartz, Elisabetta Pupillo, Milica Pejovic-Milovancevic, Antonia Ratti, Henrik B. Rasmussen, Kari Stefansson, Brendan Bulik-Sullivan, Béla Melegh, Stéphanie Millecamps, Janis Klovins, Enrico Domenici, Michael Sendtner, Kai-How Farh, Randy L. Buckner, Albert Hofman, Benjamin M. Neale, Naomi R. Wray, An Goris, Kang Sim, Lauren Elman, Giulio Genovese, Jens R. Wendland, Rita M. Cantor, Ariel Darvasi, Christina M. Hultman, Sandra D'Alfonso, Cristina Moglia, Carlos N. Pato, Sena Karachanak-Yankova, Nicholas John Craddock, Richard W. Orrell, Richard Bruggeman, Kenneth S. Kendler, Alan M. Pittman, Robin M. Murray, Richard E. Straub, Cathryn M. Lewis, Srdjan Djurovic, Vincent Meininger, Jeffrey A. Lieberman, Bertram Müller-Myhsok, Phil Lee, David J. Kavanagh, Srihari Gopal, Igor Nenadic, Matthew C. Keller, Christian R. Schubert, Jacob Gratten, Alexandra Durr, Roger Pamphlett, Douglas F. Levinson, Luba Kalaydjieva, Chiara Zecca, Anil K. Malhotra, Andre Franke, Vaughan J. Carr, Steven A. McCarroll, C. Robert Cloninger, Judit Bene, Ina Giegling, Wei Cheng, Hualin Simon Xi, Thomas Werge, Eric Strengman, Susanne Petri, Engilbert Sigurdsson, Mark Hansen, Patrick F. Sullivan, Kieran C. Murphy, Inge Joa |
|---|---|
| Přispěvatelé: | Complex Trait Genetics, McLaughlin, Russell L, Schijven, Dick, Van Rheenen, Wouter, Van Eijk, Kristel R, O'Brien, Margaret, Kahn, René S, Ophoff, Roel A, Goris, An, Bradley, Daniel G, Al-Chalabi, Ammar, Van Den Berg, Leonard H, Luykx, Jurjen J, Hardiman, Orla, Veldink, Jan H, Lee, S Hong, Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Kučinskas, Vaidutis, Kučinskienė, Zita Aušrelė, Other departments, Neurology, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, Schizophrenia Working Group of the Psychiatric Genomics Consortiumz, Germeys, Inez, Robberecht, Wim, Van Damme, Philip |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Genetics and Molecular Biology (all) Linkage disequilibrium Multifactorial Inheritance General Physics and Astronomy Genome-wide association study Comorbidity VARIANTS Neurodegenerative Biochemistry DISEASE 3124 Neurology and psychiatry Linkage Disequilibrium Cohort Studies 0302 clinical medicine Genetics research Odds Ratio 2.1 Biological and endogenous factors Amyotrophic lateral sclerosis Aetiology ARCHITECTURE Schizophrenia Working Group of the Psychiatric Genomics Consortium Multidisciplinary Chemistry (all) Motor neuron disease Schizophrenia BIPOLAR DISORDER Single Nucleotide Serious Mental Illness 3. Good health Mental Health RC0346 motor neuron disease Project MinE GWAS Consortium medicine.medical_specialty SUSCEPTIBILITY LOCI Science European Continental Ancestry Group Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Article White People 03 medical and health sciences Physics and Astronomy (all) Rare Diseases SDG 3 - Good Health and Well-being Clinical Research Internal medicine MD Multidisciplinary mental disorders medicine Genetics Journal Article Humans Genetic Predisposition to Disease Family Bipolar disorder GENOME-WIDE ASSOCIATION Polymorphism Biology METAANALYSIS business.industry Amyotrophic Lateral Sclerosis Human Genome Case-control study 3112 Neurosciences Neurosciences General Chemistry Odds ratio medicine.disease R1 Brain Disorders 030104 developmental biology genetics research Case-Control Studies RC0321 Linear Models PLEIOTROPY Human medicine 3111 Biomedicine Biochemistry Genetics and Molecular Biology (all) ALS business 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Nature Communications, 8:14774. Nature Publishing Group Nature Communications Nature communications, vol 8, iss 1 McLaughlin, R L, Schijven, D, van Rheenen, W, van Eijk, K R, O'Brien, M, Kahn, R S, Ophoff, R A, Goris, A, Bradley, D G, Al-Chalabi, A, van den Berg, L H, Luykx, J J, Hardiman, O, Veldink, J H & Project MinE GWAS Consortium 2017, ' Genetic correlation between amyotrophic lateral sclerosis and schizophrenia ', Nature Communications, vol. 8, 14774, pp. 14774 . https://doi.org/10.1038/ncomms14774 BASE-Bielefeld Academic Search Engine Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017) McLaughlin, R L, Schijven, D, van Rheenen, W, van Eijk, K R, O'Brien, M, Kahn, R S, Ophoff, R A, Goris, A, Bradley, D G, Al-Chalabi, A, van den Berg, L H, Luykx, J J, Hardiman, O, Veldink, J H & Project MinE GWAS Consortium 2017, ' Genetic correlation between amyotrophic lateral sclerosis and schizophrenia ', Nature Communications, vol. 8, 14774, pp. 1-12 . https://doi.org/10.1038/ncomms14774 Nature communications, London, Nature Publishing Group, 2017, Vol. 8, Art. No. 14774 Nature communications, 8. Nature Publishing Group Nature communications McLaughlin, Russell L; Schijven, Dick; van Rheenen, Wouter; van Eijk, Kristel R; O'Brien, Margaret; Kahn, René S; et al.(2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.. Nature communications, 8(1), 14774. doi: 10.1038/ncomms14774. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/6r8064rn McLaughlin, R L, Schijven, D, Van Rheenen, W, Van Eijk, K R, O'Brien, M, Kahn, R S, Ophoff, R A, Goris, A, Bradley, D G, Al-Chalabi, A, Van Den Berg, L H, Luykx, J J, Hardiman, O, Veldink, J H, Shatunov, A, Dekker, A M, Diekstra, F P, Pulit, S L, Van Der Spek, R A A, Van Doormaal, P T C, Sproviero, W, Jones, A R, Nicholson, G A, Rowe, D B, Pamphlett, R, Kiernan, M C, Bauer, D, Kahlke, T, Williams, K, Eftimov, F, Fogh, I, Ticozzi, N, Lin, K, Millecamps, S, Salachas, F, Meininger, V, Carvalho, M D, Pinto, S, Mora, J S, Rojas-Garcyá, R, Polak, M, Chandran, S, Andersen, P M, Pers, T H, Hansen, M, Hansen, T, Li, T, Olsen, L, Rasmussen, H B, Werge, T & Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2017, ' Genetic correlation between amyotrophic lateral sclerosis and schizophrenia ', Nature Communications, vol. 8, 14774 . https://doi.org/10.1038/ncomms14774 r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Instituto de Salud Carlos III (ISCIII) Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2017, ' Genetic correlation between amyotrophic lateral sclerosis and schizophrenia ', Nature Communications, vol. 8, pp. 14774 . https://doi.org/10.1038/ncomms14774 Nature Communications [E], 8. Nature Publishing Group McLaughlin, R L, Schijven, D, Van Rheenen, W, Van Eijk, K R, O'Brien, M, Kahn, R S, Ophoff, R A, Goris, A, Bradley, D G, Al-Chalabi, A, Van Den Berg, L H, Luykx, J J, Hardiman, O, Veldink, J H, Shatunov, A, Dekker, A M, Diekstra, F P, Pulit, S L, Van Der Spek, R A A, Van Doormaal, P T C, Sproviero, W, Jones, A R, Nicholson, G A, Rowe, D B, Pamphlett, R, Kiernan, M C, Bauer, D, Kahlke, T, Williams, K, Eftimov, F, Fogh, I, Ticozzi, N, Lin, K, Millecamps, S, Salachas, F, Meininger, V, Carvalho, M D, Pinto, S, Mora, J S, Rojas-Garcyá, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, K E, Shaw, P J, Hardy, J, Orrell, R W, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Wiedau-Pazos, M, Lomen-Hoerth, C, Deerlin, V M V, Trojanowski, J Q, Elman, L, McCluskey, L, Basak, N, Meitinger, T, Lichtner, P, Blagojevic-Radivojkov, M, Andres, C R, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, C A M, Saker-Delye, S, Durr, A, Wood, N, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nothen, M M, Amouyel, P, Tzourio, C, Dartigues, J F, Uitterlinden, A G, Rivadeneira, F, Estrada, K, Hofman, A, Curtis, C, Derkooi, A J V, De Visser, M, Weber, M, Shaw, C E, Smith, B N, Pansarasa, O, Cereda, C, Bo, R D, Comi, G P, D'Alfonso, S, Bertolin, C, Soraru, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Blair, I, Nigel Leigh, P, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, A C, Weishaupt, J H, Robberecht, W, Damme, P V, Brown, R H, Glass, J, Landers, J E, Andersen, P M, Corcia, P, Vourc'H, P, Silani, V, Es, M A V, Pasterkamp, R J, Lewis, C M, Breen, G, Ripke, S, Neale, B M, Corvin, A, Walters, J T R, Farh, K H, Holmans, P A, Lee, P, Bulik-Sullivan, B, Collier, D A, Huang, H, Pers, T H, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, S A, Begemann, M, Belliveau, R A, Bene, J, Bergen, S E, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Byerley, W, Cahn, W, Cai, G, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Chan, R C K, Chan, R Y L, Chen, E Y H, Cheng, W, Cheung, E F C, Chong, S A, Cloninger, C R, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Degenhardt, F, Favero, J D, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farrell, M S, Frank, J, Franke, L, Freedman, R, Freimer, N B, Friedl, M, Friedman, J I, Fromer, M, Genovese, G, Georgieva, L, Giegling, I, Giusti-Rodrýguez, P, Godard, S, Goldstein, J I, Golimbet, V, Gopal, S, Gratten, J, De Haan, L, Hammer, C, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Herms, S, Hirschhorn, J N, Hoffmann, P, Hofman, A, Hollegaard, M V, Hougaard, D M, Ikeda, M, Joa, I, Julia, A, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Keller, M C, Kennedy, J L, Khrunin, A, Kim, Y, Klovins, J, Knowles, J A, Konte, B, Kucinskas, V, Kucinskiene, Z A, Kuzelova-Ptackova, H, Kahler, A K, Laurent, C, Lee, J, Hong Lee, S, Legge, S E, Lerer, B, Li, M, Li, T, Liang, K Y, Lieberman, J, Limborska, S, Loughland, C M, Lubinski, J, Lonnqvist, J, MacEk, M, Magnusson, P K E, Maher, B S, Maier, W, Mallet, J, Marsal, S, Mattheisen, M, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S, Meijer, C J, Melegh, B, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Mors, O, Murphy, K C, Murray, R M, Myin-Germeys, I, Muller-Myhsok, B, Nelis, M, Nenadic, I, Nertney, D A, Nestadt, G, Nicodemus, K K, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, Anthony O'Neill, F, Oh, S Y, Olincy, A, Olsen, L, Vanos, J, Pantelis, C, Papadimitriou, G N, Papiol, S, Parkhomenko, E, Pato, M T, Paunio, T, Pejovic-Milovancevic, M, Perkins, D O, Pietilainen, O, Pimm, J, Pocklington, A J, Price, A, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Ruderfer, D M, Salomaa, V, Sanders, A R, Schall, U, Schubert, C R, Schulze, T G, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, J M, Sim, K, Slominsky, P, Smoller, J W, So, H C, Spencer, C C A, Stah, E A, Stefansson, H, Steinberg, S, Stogmann, E, Straub, R E, Strengman, E, Strohmaier, J, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Williams, S, Witt, S H, Wolen, A R, Wong, E H M, Wormley, B K, Xi, H S, Zai, C C, Zheng, X, Zimprich, F, Wray, N R, Stefansson, K, Visscher, P M, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Børglum, A D, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, P V, Gil, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jonsson, E G, Kendler, K S, Kirov, G, Knight, J, Lencz, T, Levinson, D F, Li, Q S, Liu, J, Malhotra, A K, McCarrol, S A, McQuillin, A, Moran, J L, Mortensen, P B, Mowry, B J, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Riley, B P, Rujescu, D, Sham, P C, Sklar, P, Clair, D S, Weinberger, D R, Wendland, J R, Werge, T, Daly, M J, Sullivan, P F & O'Donovan, M C 2017, ' Genetic correlation between amyotrophic lateral sclerosis and schizophrenia ', Nature Communications, vol. 8, 14774 . https://doi.org/10.1038/ncomms14774 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms14774 |
| Popis: | We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10−4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10−7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies. Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms. |
| Databáze: | OpenAIRE |
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