Early post‐treatment blood oxygenation level‐dependent responses to emotion processing associated with clinical response to pharmacological treatment in major depressive disorder
| Autor: | Rajamannar Ramasubbu, Rebecca J. Williams, G. Bruce Pike, Elliot C. Brown, Darren L. Clark |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Middle temporal gyrus Emotions Neurosciences. Biological psychiatry. Neuropsychiatry Superior parietal lobule Citalopram behavioral disciplines and activities Brain mapping facial recognition Behavioral Neuroscience Internal medicine medicine Humans Original Research Depressive Disorder Major major depressive disorder medicine.diagnostic_test business.industry Precentral gyrus Inferior parietal lobule medicine.disease functional magnetic resonance imaging Magnetic Resonance Imaging Facial Expression Cardiology brain mapping Major depressive disorder Functional magnetic resonance imaging business Insula antidepressant agents RC321-571 |
| Zdroj: | Brain and Behavior Brain and Behavior, Vol 11, Iss 8, Pp n/a-n/a (2021) |
| ISSN: | 2162-3279 |
| DOI: | 10.1002/brb3.2287 |
| Popis: | Introduction Pre‐treatment blood oxygenation level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) has been used for the early identification of patients with major depressive disorder (MDD) who later respond or fail to respond to medication. However, BOLD responses early after treatment initiation may offer insight into early neural changes associated with later clinical response. The present study evaluated both pre‐treatment and early post‐treatment fMRI responses to an emotion processing task, to further our understanding of neural changes associated with a successful response to pharmacological intervention. Methods MDD patients who responded (n = 22) and failed to respond (n = 12) after 8 weeks of treatment with either citalopram or quetiapine extended release, and healthy controls (n = 18) underwent two fMRI scans, baseline (pre‐treatment), and early post‐treatment (one week after treatment commencement). Participants completed an emotional face matching task at both scans. Results Using threshold‐free cluster enhancement (TFCE) and non‐parametric permutation testing, fMRI activation maps showed that after one week of treatment, responders demonstrated increased activation in the left parietal lobule, precentral gyrus, and bilateral insula (all P Patients diagnosed MDD who later went on to respond to medication showed robust BOLD increases after one week of treatment to an emotion processing task. There were no differences between responders, non‐responders and healthy controls at baseline, indicating that BOLD fMRI can be used to identify mediating markers of treatment response. |
| Databáze: | OpenAIRE |
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