[Myelopeptide MP-5 and fluorescent derivatives: synthesis and biological activity]
| Autor: | R. G. Belevskaya, A. A. Mikhailova, L. A. Fonina, Z. A. Ardemasova, A. A. Az’muko, M. A. Efremov, M. L. Lewit, E. M. Treshchalina, S. A. Gur'yanov, V. N. Kalikhevich |
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| Předmět: |
T-Lymphocytes
Peptide Antineoplastic Agents Biology Biochemistry Mice In vivo Cell Line Tumor medicine Bioorganic chemistry Animals Immunologic Factors Cell Proliferation Fluorescent Dyes chemistry.chemical_classification Melanoma Organic Chemistry Biological activity medicine.disease Xenograft Model Antitumor Assays In vitro medicine.anatomical_structure chemistry Cell culture Bone marrow Oligopeptides |
| Zdroj: | Scopus-Elsevier |
| Popis: | The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and an analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The biological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60-84% inhibition of growth of the following mouse cancers: lymphatic leukemia P-388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 toward T lymphocytes, but Ftc-MP-5 was practically inactive. |
| Databáze: | OpenAIRE |
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