Delayed pubertal onset and development in German children and adolescents with type 1 diabetes: cross-sectional analysis of recent data from the DPV diabetes documentation and quality management system
| Autor: | Tilman Rohrer, Eva Stierkorb, Sabine Heger, Beate Karges, Klemens Raile, K Otfried Schwab, Reinhard W Holl |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Endocrinology Diabetes and Metabolism Population Pubarche Child Development Endocrinology Germany Internal medicine Diabetes mellitus medicine Humans Longitudinal Studies Prospective Studies Thelarche Child education Menarche Puberty Delayed Type 1 diabetes education.field_of_study business.industry Puberty Disease Management General Medicine medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Female Age of onset business Body mass index |
| Zdroj: | European Journal of Endocrinology. 157:647-653 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-07-0150 |
| Popis: | ObjectiveTo investigate the effect of type 1 diabetes on pubertal onset and development, and to identify factors potentially affecting puberty, including glycemic control, relative diabetes duration, body mass index standard delta score (BMI SDS), insulin dose, and intensity of insulin therapy.Research design and methodsInitiated in 1990, the Diabetes-Patienten-Verlaufsdaten (DPV) is an ongoing, prospective longitudinal follow-up program to benchmark the quality of diabetes care provided to, predominantly, pediatric patients. Data collection for this non-interventional audit was carried out at 202 German diabetes treatment centers. Patient recruitment was done by referral, clinic/hospital ascertainment, or self-report. Data were analyzed for subcohorts of 1218–2409 boys and 579–2640 girls from a cohort of 24 385 pediatric type 1 diabetic patients. Selection was based on ethnicity and availability of data on Tanner stage 2, or higher, of genital and pubic hair development (boys) or breast and pubic hair development, and menarche (girls).ResultsBoys showed significant (PConclusionsPubertal onset, but not sexual maturity, is delayed in children with type 1 diabetes. Delay increases with higher glycohemoglobin and lower BMI SDS. |
| Databáze: | OpenAIRE |
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