10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
| Autor: | N Smith, Daniel Kramer, D W Scott, P Salmikangas, Anna Fogdell-Hahn, Sebastian Spindeldreher, Vibha Jawa, S Pattijn, V Snoeck, Joao Pedras-Vasconcelos, N Legrand, Philippe Broët, Sophie Tourdot, J Bessa, K Kuranda, A Rudy, Mario Giorgi, A Abdolzade-Bavil |
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| Rok vydání: | 2020 |
| Předmět: |
ADA testing
Training course Immunology chemical and pharmacologic phenomena Context (language use) Meeting Report complex mixtures 03 medical and health sciences 0302 clinical medicine Immunology and Allergy Medicine 030304 developmental biology 0303 health sciences business.industry Immunogenicity Conventional treatment risk assessment Meeting place clinical relevance Treatment efficacy Tolerance induction Drug activity 030220 oncology & carcinogenesis Engineering ethics business |
| Zdroj: | mAbs |
| ISSN: | 1942-0870 1942-0862 |
| Popis: | Therapeutic proteins and emerging gene and cell-based therapies are attractive therapeutic tools for addressing unmet medical needs or when earlier conventional treatment approaches failed. However, the development of an immune response directed against therapeutic agents is a significant concern as it occurs in a substantial number of cases across products and indications. The specific anti-drug antibodies that develop can lead to safety adverse events as well as inhibition of drug activity or accelerated clearance, both phenomena resulting in loss of treatment efficacy. The European Immunogenicity Platform (EIP) is a meeting place for experts and newcomers to the immunogenicity field, designed to stimulate discussion amongst scientists across industry and academia, encourage interactions with regulatory agencies and share knowledge and the state-of-the-art of immunogenicity sciences with the broader scientific community. Here we report on the main topics covered during the EIP 10th Open Symposium on Immunogenicity of Biopharmaceuticals held in Lisbon, 26–27 February 2019, and the 1-d training course on practical and regulatory aspects of immunogenicity held ahead of the conference. These main topics included immunogenicity testing, clinical relevance of immunogenicity, immunogenicity prediction, regulatory aspects, tolerance induction as a mean to mitigate immunogenicity and immunogenicity in the context of gene therapy. |
| Databáze: | OpenAIRE |
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