Modulating Cell Fate as a Therapeutic Strategy
| Autor: | Alison C. Castle, Rajeev Malhotra, Jayaraj Rajagopal, Priya Srikanth, Brian M. Lin, David B. Sykes, Sagar U. Nigwekar, Jenna L. Galloway |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Regeneration (biology) Cell Plasticity Cell Biology Cell fate determination Biology Plasticity Regenerative Medicine Regenerative medicine Article 03 medical and health sciences 030104 developmental biology Cellular plasticity Genetics Molecular Medicine Animals Humans Neuroscience Therapeutic strategy |
| Zdroj: | Cell stem cell. 23(3) |
| ISSN: | 1875-9777 |
| Popis: | In injured tissues, regeneration is often associated with cell fate plasticity, such that cells deviate from their normal lineage paths. It is becoming increasingly clear that this plasticity often creates alternative strategies to restore damaged or lost cells. Alternatively, cell fate plasticity is also part and parcel of pathologic tissue transformations that accompany disease. In this Perspective, we summarize a few illustrative examples of physiologic and aberrant cellular plasticity. Then we speculate on how one could enhance endogenous plasticity to promote regeneration and reverse pathologic plasticity, perhaps inspiring interest in a new class of therapies targeting cell fate modulation. |
| Databáze: | OpenAIRE |
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