Immune Inhibition of Virus Release from Herpes Simplex Virus-Infected Cells by Human Sera
| Autor: | D. Shariff, J. A. Hallworth, G.R.B. Skinner, M. Desperbasques, A. Buchan |
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| Rok vydání: | 1988 |
| Předmět: |
Blood Bactericidal Activity
Herpes Genitalis biology In Vitro Techniques Antibodies Viral biology.organism_classification medicine.disease_cause Virology Neutralization Virus Virus Release Herpesviridae Infectious Diseases Herpes simplex virus Neutralization Tests Alphaherpesvirinae Immunology biology.protein medicine Humans Simplexvirus Herpes Labialis Antibody Neutralizing antibody |
| Zdroj: | Intervirology. 29:125-132 |
| ISSN: | 1423-0100 0300-5526 |
| DOI: | 10.1159/000150038 |
| Popis: | Human sera contain antibody (IVR antibody) which will inhibit the release of herpes simplex virus type 1 from virus-infected cells. This antibody activity was removed by adsorption of sera with virus-infected cell extract. There was a positive correlation between IVR and neutralizing antibody activity, particularly when measured by augmented neutralization test; measurement of IVR antibody was equally as sensitive as measurement of neutralizing antibody by augmented neutralization test. IVR antibody levels provided indication of a history of recurrent herpes labialis, the pattern of antibody response following primary herpetic infection, and indication of response to Skinner herpes vaccine in human subjects. It is suggested that consideration should be given to measurement of IVR antibody in both clinical and epidemiological studies of herpes and other virus infections. |
| Databáze: | OpenAIRE |
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