Aging decreases the abundance of retinoic acid (RAR) and triiodothyronie (TR) nuclear receptor mRNA in rat brain : Effect of the administration of retinoids

Autor: Henri Garcin, Robert Jaffard, Paul Higueret, V Enderlin, Véronique Pallet, Serge Alfos, V Azaı̈s-Braesco
Přispěvatelé: Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA), Unité sous contrat nutrition et signalisation cellulaire, Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Neurosciences cognitives (NC), Université Sciences et Technologies - Bordeaux 1 (UB)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration
Jazyk: angličtina
Rok vydání: 1997
Předmět:
Male
Aging
Retinyl Esters
TR
MESH: Diterpenes
Receptors
Retinoic Acid
Tissue transglutaminase
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Retinoic acid
Biochemistry
chemistry.chemical_compound
Structural Biology
MESH: Aging
MESH: Animals
Retinoid
Vitamin A
Receptor
Intubation
Gastrointestinal
MESH: Vitamin A
Receptors
Thyroid Hormone
Triiodothyronine
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Age Factors
Brain
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
MESH: Intubation
Gastrointestinal
VIELLISSEMENT
Diterpenes
medicine.medical_specialty
MESH: Rats
medicine.drug_class
mRNA
Biophysics
Tretinoin
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
MESH: Brain
Internal medicine
Genetics
medicine
Animals
RNA
Messenger
MESH: Receptors
Thyroid Hormone
Rats
Wistar
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Molecular Biology
MESH: RNA
Messenger
MESH: Age Factors
MESH: Receptors
Retinoic Acid
Messenger RNA
MESH: Tretinoin
MESH: Rats
Wistar
Cell Biology
MESH: Male
Rats
Endocrinology
Nuclear receptor
chemistry
biology.protein
RAR
Hormone
Zdroj: FEBS Letters
FEBS Letters, Wiley, 1997, 412, pp.629-632
FEBS Letters, 1997, 412 (3), pp.629-632. ⟨10.1016/s0014-5793(97)00845-4⟩
ISSN: 0014-5793
1873-3468
DOI: 10.1016/s0014-5793(97)00845-4⟩
Popis: International audience; Aging is accompanied by troubles resulting from changes in hormonal and nutritional status. Therefore, the abundance of mRNA coding for triiodothyronine (TR) and retinoic acid (RA) nuclear receptors was studied in the brain of young, adult and aged (2.5, 6 and 24 months, respectively) rats. In the brain of aged rats, there was a lower abundance of TR and RAR mRNA and a lower activity of tissue transglutaminase (tTG), an enzyme the gene of which is a target for retinoids. Administration of RA in these rats restored TR and RAR mRNA and the activity of tTG in the brain. The importance of these observations to the function of the aged brain is discussed.
Databáze: OpenAIRE
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